Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy
Cytotoxic chemotherapy prolongs survival of patients with advanced and metastatic tumors. This is, however, a double-edged sword with many adverse effects. Since the liver has a rich blood supply and plays an active role in the metabolism of medications, it is not surprising that there can be hepati...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2013/815105 |
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| _version_ | 1832561877147713536 |
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| author | Y. Maor S. Malnick |
| author_facet | Y. Maor S. Malnick |
| author_sort | Y. Maor |
| collection | DOAJ |
| description | Cytotoxic chemotherapy prolongs survival of patients with advanced and metastatic tumors. This is, however, a double-edged sword with many adverse effects. Since the liver has a rich blood supply and plays an active role in the metabolism of medications, it is not surprising that there can be hepatic injury related to chemotherapy. In addition, radioembolization may affect the parenchyma of normal and cirrhotic livers. We review chemotherapy-associated liver injury in patients with colorectal liver metastases, including downsizing chemotherapy and neoadjuvant chemotherapy. We discuss the mechanism of the hepatic injury, secondary to reactive oxygen species, and the spectrum of hepatic injury including, steatosis, steatohepatitis, hepatic sinusoidal injury and highlight the pharmacogenomics of such liver insults. Methods for reducing and treating the hepatotoxicity are discussed for specific agents including tamxifen and the newly introduced targeted antibodies. |
| format | Article |
| id | doaj-art-dbc1c38ba1124789b31d0a10c3931325 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-dbc1c38ba1124789b31d0a10c39313252025-02-03T01:24:05ZengWileyInternational Journal of Hepatology2090-34482090-34562013-01-01201310.1155/2013/815105815105Liver Injury Induced by Anticancer Chemotherapy and Radiation TherapyY. Maor0S. Malnick1Department of Gastroenterology and Hepatology, Sheba Medical Center, 52621 Tel-Hashomer, IsraelDepartment of Internal Medicine C, Kaplan Medical Center, The Hebrew University of Jerusalem, 76100 Rehovot, IsraelCytotoxic chemotherapy prolongs survival of patients with advanced and metastatic tumors. This is, however, a double-edged sword with many adverse effects. Since the liver has a rich blood supply and plays an active role in the metabolism of medications, it is not surprising that there can be hepatic injury related to chemotherapy. In addition, radioembolization may affect the parenchyma of normal and cirrhotic livers. We review chemotherapy-associated liver injury in patients with colorectal liver metastases, including downsizing chemotherapy and neoadjuvant chemotherapy. We discuss the mechanism of the hepatic injury, secondary to reactive oxygen species, and the spectrum of hepatic injury including, steatosis, steatohepatitis, hepatic sinusoidal injury and highlight the pharmacogenomics of such liver insults. Methods for reducing and treating the hepatotoxicity are discussed for specific agents including tamxifen and the newly introduced targeted antibodies.http://dx.doi.org/10.1155/2013/815105 |
| spellingShingle | Y. Maor S. Malnick Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy International Journal of Hepatology |
| title | Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy |
| title_full | Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy |
| title_fullStr | Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy |
| title_full_unstemmed | Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy |
| title_short | Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy |
| title_sort | liver injury induced by anticancer chemotherapy and radiation therapy |
| url | http://dx.doi.org/10.1155/2013/815105 |
| work_keys_str_mv | AT ymaor liverinjuryinducedbyanticancerchemotherapyandradiationtherapy AT smalnick liverinjuryinducedbyanticancerchemotherapyandradiationtherapy |