The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review
Myocardial infarction has been a serious threat to human health due to its high morbidity and mortality all over the world. The major problem is the loss of limited regenerative cardiomyocytes and occurrence of inflammatory response, leading to the formation of non-contractile and non-conducting fib...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Smart Materials in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590183424000668 |
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| author | Songtao Zhang Ziyi Shao Yihong Wu Yongyi Song Yaxi He Zongyi Liu Xiaodong Fu Leyu Wang |
| author_facet | Songtao Zhang Ziyi Shao Yihong Wu Yongyi Song Yaxi He Zongyi Liu Xiaodong Fu Leyu Wang |
| author_sort | Songtao Zhang |
| collection | DOAJ |
| description | Myocardial infarction has been a serious threat to human health due to its high morbidity and mortality all over the world. The major problem is the loss of limited regenerative cardiomyocytes and occurrence of inflammatory response, leading to the formation of non-contractile and non-conducting fibrotic scar tissue. Thus, it disrupts the mechano-electric coupling system of the heart, negatively influencing the heart function. Recently, the conductive cardiac patches with advantage of reconstructing electrical propagation have been extensively applied for cardiac repair. This review introduces a detailed overview of the recent progress in cardiac electrophysiology-inspired patches for cardiac repair from three parts of the construction and functionality of mechano-electric coupling cardiac patches, the construction and functionality of microstructure of the cardiac patches, the realtime detection based on mechano-electric transformation. Finally, the achievements and future perspective of conductive cardiac patches is discussed from the aspects of biosafety, further exploration of factors affecting mechano-electric coupling in cardiac patches and regulation of detection. It is hopeful to help researchers understand the functional components and development of conductive cardiac patches for cardiac repair, as well as to inspire them to synthesize novel cardiac patches for promoting clinical translation. |
| format | Article |
| id | doaj-art-dbc0c43265f846d0b065e184556a34b7 |
| institution | DOAJ |
| issn | 2590-1834 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Smart Materials in Medicine |
| spelling | doaj-art-dbc0c43265f846d0b065e184556a34b72025-08-20T02:53:41ZengKeAi Communications Co., Ltd.Smart Materials in Medicine2590-18342025-03-016110811910.1016/j.smaim.2024.12.003The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A reviewSongtao Zhang0Ziyi Shao1Yihong Wu2Yongyi Song3Yaxi He4Zongyi Liu5Xiaodong Fu6Leyu Wang7Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China; Department of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, ChinaDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, ChinaDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, ChinaDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, ChinaGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, ChinaGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China; Corresponding author.Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China; Corresponding author. Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China.Myocardial infarction has been a serious threat to human health due to its high morbidity and mortality all over the world. The major problem is the loss of limited regenerative cardiomyocytes and occurrence of inflammatory response, leading to the formation of non-contractile and non-conducting fibrotic scar tissue. Thus, it disrupts the mechano-electric coupling system of the heart, negatively influencing the heart function. Recently, the conductive cardiac patches with advantage of reconstructing electrical propagation have been extensively applied for cardiac repair. This review introduces a detailed overview of the recent progress in cardiac electrophysiology-inspired patches for cardiac repair from three parts of the construction and functionality of mechano-electric coupling cardiac patches, the construction and functionality of microstructure of the cardiac patches, the realtime detection based on mechano-electric transformation. Finally, the achievements and future perspective of conductive cardiac patches is discussed from the aspects of biosafety, further exploration of factors affecting mechano-electric coupling in cardiac patches and regulation of detection. It is hopeful to help researchers understand the functional components and development of conductive cardiac patches for cardiac repair, as well as to inspire them to synthesize novel cardiac patches for promoting clinical translation.http://www.sciencedirect.com/science/article/pii/S2590183424000668Myocardial infarctionCardiac patchElectrophysiologyCardiac repairMechano-electric coupling |
| spellingShingle | Songtao Zhang Ziyi Shao Yihong Wu Yongyi Song Yaxi He Zongyi Liu Xiaodong Fu Leyu Wang The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review Smart Materials in Medicine Myocardial infarction Cardiac patch Electrophysiology Cardiac repair Mechano-electric coupling |
| title | The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review |
| title_full | The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review |
| title_fullStr | The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review |
| title_full_unstemmed | The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review |
| title_short | The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review |
| title_sort | cardiac electrophysiology inspired patches for repairing myocardial infarction a review |
| topic | Myocardial infarction Cardiac patch Electrophysiology Cardiac repair Mechano-electric coupling |
| url | http://www.sciencedirect.com/science/article/pii/S2590183424000668 |
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