Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host health
Bacteria have been known to reside in the human gut for roughly two centuries, but their modulatory effects on host health status are still not fully characterized. The gut microbiota is known to interact with dietary components and nutrients, producing functional metabolites that may alter host met...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2125734 |
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| author | Andrew Gold Jiangjiang Zhu |
| author_facet | Andrew Gold Jiangjiang Zhu |
| author_sort | Andrew Gold |
| collection | DOAJ |
| description | Bacteria have been known to reside in the human gut for roughly two centuries, but their modulatory effects on host health status are still not fully characterized. The gut microbiota is known to interact with dietary components and nutrients, producing functional metabolites that may alter host metabolic processes. The majority of thoroughly researched and understood gut microbial metabolites fall into two categories: short-chain fatty acids (SCFAs) and bacterial derivatives of dietary tryptophan. Despite the heavy emphasis on these metabolites, other metabolites stemming from microbial origin have significant impacts on host health and disease states. In this narrative review, we summarize eight recent studies elucidating novel bacterial metabolites, detailing the process by which these metabolites are identified, their actions within specific categories of human health, and how diet may impact production of these metabolites. With similar future mechanistic research, a more complete picture of bacterial impact on host metabolism may be constructed. |
| format | Article |
| id | doaj-art-dbbe519e99ef4b28b872f09724a7ebe1 |
| institution | OA Journals |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-dbbe519e99ef4b28b872f09724a7ebe12025-08-20T02:38:11ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2125734Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host healthAndrew Gold0Jiangjiang Zhu1Human Nutrition Program & James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USAHuman Nutrition Program & James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USABacteria have been known to reside in the human gut for roughly two centuries, but their modulatory effects on host health status are still not fully characterized. The gut microbiota is known to interact with dietary components and nutrients, producing functional metabolites that may alter host metabolic processes. The majority of thoroughly researched and understood gut microbial metabolites fall into two categories: short-chain fatty acids (SCFAs) and bacterial derivatives of dietary tryptophan. Despite the heavy emphasis on these metabolites, other metabolites stemming from microbial origin have significant impacts on host health and disease states. In this narrative review, we summarize eight recent studies elucidating novel bacterial metabolites, detailing the process by which these metabolites are identified, their actions within specific categories of human health, and how diet may impact production of these metabolites. With similar future mechanistic research, a more complete picture of bacterial impact on host metabolism may be constructed.https://www.tandfonline.com/doi/10.1080/19490976.2022.2125734Microbial metaboliteshost healthmechanismmetabolomics |
| spellingShingle | Andrew Gold Jiangjiang Zhu Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host health Gut Microbes Microbial metabolites host health mechanism metabolomics |
| title | Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host health |
| title_full | Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host health |
| title_fullStr | Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host health |
| title_full_unstemmed | Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host health |
| title_short | Not just a gut feeling: a deep exploration of functional bacterial metabolites that can modulate host health |
| title_sort | not just a gut feeling a deep exploration of functional bacterial metabolites that can modulate host health |
| topic | Microbial metabolites host health mechanism metabolomics |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2125734 |
| work_keys_str_mv | AT andrewgold notjustagutfeelingadeepexplorationoffunctionalbacterialmetabolitesthatcanmodulatehosthealth AT jiangjiangzhu notjustagutfeelingadeepexplorationoffunctionalbacterialmetabolitesthatcanmodulatehosthealth |