Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer
Objective.To examine gastrointestinal (GI) and genitourinary (GU) toxicity profiles of patients treated in 1999 with external beam radiotherapy (RT), prostate interstitial brachytherapy (PI) or radical prostatectomy (RP). Methods. TThe records of 525 patients treated in 1999 were reviewed to evaluat...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/853487 |
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| author | Grant K. Hunter Chandana A. Reddy Eric A. Klein Patrick Kupelian Kenneth Angermeier James Ulchaker Nabil Chehade Andrew Altman Jay P. Ciezki |
| author_facet | Grant K. Hunter Chandana A. Reddy Eric A. Klein Patrick Kupelian Kenneth Angermeier James Ulchaker Nabil Chehade Andrew Altman Jay P. Ciezki |
| author_sort | Grant K. Hunter |
| collection | DOAJ |
| description | Objective.To examine gastrointestinal (GI) and genitourinary (GU) toxicity profiles of patients treated in 1999 with external beam radiotherapy (RT), prostate interstitial brachytherapy (PI) or radical prostatectomy (RP). Methods. TThe records of 525 patients treated in 1999 were reviewed to evaluate toxicity. Late GI and GU morbidities were graded according to the RTOG late morbidity criteria. Other factors examined were patient age, BMI, smoking history, and medical co-morbidities. Due to the low event rate for late GU and GI toxicities, a competing risk regression (CRR) analysis was done with death as the competing event. Results. Median follow-up time was 8.5 years. On CRR univariate analysis, only the presence of DM was significantly associated with GU toxicity grade >2 (𝑃=0.43, HR 2.35, 95% Cl = 1.03–5.39). On univariate analysis, RT and DM were significantly associated with late GI toxicity. On multivariable analysis, both variables remained significant (RT: 𝑃=0.038, HR=4.71, CI=1.09–20.3; DM: 𝑃=0.008, HR=3.81, 95% Cl = 1.42–10.2). Conclusions. Late effects occur with all treatment modalities. The presence of DM at the time of treatment was significantly associated with worse late GI and GU toxicity. RT was significantly associated with worse late GI toxicity compared to PI and RP. |
| format | Article |
| id | doaj-art-dbbc4453394b4281b4418460facd3444 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-dbbc4453394b4281b4418460facd34442025-02-03T01:23:26ZengWileyProstate Cancer2090-31112090-312X2012-01-01201210.1155/2012/853487853487Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate CancerGrant K. Hunter0Chandana A. Reddy1Eric A. Klein2Patrick Kupelian3Kenneth Angermeier4James Ulchaker5Nabil Chehade6Andrew Altman7Jay P. Ciezki8Cleveland Clinic Department of Radiation Oncology, 9500 Euclid Avenue, Cleveland, OH 44195, USACleveland Clinic Department of Radiation Oncology, 9500 Euclid Avenue, Cleveland, OH 44195, USACleveland Clinic GlickmanUrological and Kidney Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USAUCLA Jonsson Comprehensive Cancer Center, 200 UCLA Medical Plaza, Suite B265, Los Angeles, CA 90095-6951, USACleveland Clinic GlickmanUrological and Kidney Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USACleveland Clinic GlickmanUrological and Kidney Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USADepartment of Urology, Kaiser Permanente, Ohio, 12301 Snow Road, Parma, OH 44130, USADepartment of Urology, Kaiser Permanente, Ohio, 12301 Snow Road, Parma, OH 44130, USACleveland Clinic Department of Radiation Oncology, 9500 Euclid Avenue, Cleveland, OH 44195, USAObjective.To examine gastrointestinal (GI) and genitourinary (GU) toxicity profiles of patients treated in 1999 with external beam radiotherapy (RT), prostate interstitial brachytherapy (PI) or radical prostatectomy (RP). Methods. TThe records of 525 patients treated in 1999 were reviewed to evaluate toxicity. Late GI and GU morbidities were graded according to the RTOG late morbidity criteria. Other factors examined were patient age, BMI, smoking history, and medical co-morbidities. Due to the low event rate for late GU and GI toxicities, a competing risk regression (CRR) analysis was done with death as the competing event. Results. Median follow-up time was 8.5 years. On CRR univariate analysis, only the presence of DM was significantly associated with GU toxicity grade >2 (𝑃=0.43, HR 2.35, 95% Cl = 1.03–5.39). On univariate analysis, RT and DM were significantly associated with late GI toxicity. On multivariable analysis, both variables remained significant (RT: 𝑃=0.038, HR=4.71, CI=1.09–20.3; DM: 𝑃=0.008, HR=3.81, 95% Cl = 1.42–10.2). Conclusions. Late effects occur with all treatment modalities. The presence of DM at the time of treatment was significantly associated with worse late GI and GU toxicity. RT was significantly associated with worse late GI toxicity compared to PI and RP.http://dx.doi.org/10.1155/2012/853487 |
| spellingShingle | Grant K. Hunter Chandana A. Reddy Eric A. Klein Patrick Kupelian Kenneth Angermeier James Ulchaker Nabil Chehade Andrew Altman Jay P. Ciezki Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer Prostate Cancer |
| title | Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer |
| title_full | Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer |
| title_fullStr | Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer |
| title_full_unstemmed | Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer |
| title_short | Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer |
| title_sort | long term 10 year gastrointestinal and genitourinary toxicity after treatment with external beam radiotherapy radical prostatectomy or brachytherapy for prostate cancer |
| url | http://dx.doi.org/10.1155/2012/853487 |
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