Mechanical stimulation prevents impairment of axon growth and overcompensates microtubule destabilization in cellular models of Alzheimer’s disease and related Tau pathologies

Mechanical stimulation prevents impairment of axon growth and overcompensates microtubule destabilization in cellular models of Alzheimer’s disease and related Tau pathologies

Alzheimer’s disease (AD) and related tauopathies such as frontotemporal dementia (FTD) or traumatic brain injury (TBI) are neurodegenerative disorders characterized by progressive loss of memory and cognitive function. The main histopathological features of AD are amyloid-β plaques and Tau neurofibr...

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Bibliographic Details
Main Authors: Alice Alessandra Galeotti, Lorenzo Santucci, Jennifer Klimek, Mohamed Aghyad Al Kabbani, Hans Zempel, Vittoria Raffa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Medicine
Subjects:
nano-pulling
mechanical stimulation
microtubule stabilization
Alzheimer’s disease
Tau pathology
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1519628/full
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