Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the Jaw
Osteonecrosis of the jaws (ONJ) is a severe complication associated with the administration of bisphosphonates, drugs used for the treatment of osteoporosis and metastatic bone disease. Bisphosphonates inhibit osteoclastic activity, preventing bone resorption and improving bone strength. However, th...
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| Format: | Article |
| Language: | English |
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Scientia Publishing House
2025-04-01
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| Series: | Juvenis Scientia |
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| Online Access: | https://jscientia.org/index.php/js/user/setLocale/en_US?source=/index.php/js/article/view/264?utm_source=doi |
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| author | Pilipov, I.A. Galstian, S.G. Timofeev, E.V. |
| author_facet | Pilipov, I.A. Galstian, S.G. Timofeev, E.V. |
| author_sort | Pilipov, I.A. |
| collection | DOAJ |
| description | Osteonecrosis of the jaws (ONJ) is a severe complication associated with the administration of bisphosphonates, drugs used for the treatment of osteoporosis and metastatic bone disease. Bisphosphonates inhibit osteoclastic activity, preventing bone resorption and improving bone strength. However, these drugs can lead to ONJ, characterized by necrosis of the jaw bone tissue, inflammation of the surrounding soft tissues, chronic pain, and an increased risk of pathological fractures. The aim of this article is to provide a comprehensive review of current data on the pathogenesis, risk factors, diagnosis, treatment, and prevention of ONJ caused by the use of bisphosphonates. The article discusses the latest advancements in understanding the pathogenesis of ONJ, including the role of systemic comorbidities and oral diseases. Current diagnostic strategies for this condition are presented. Special attention is given to the differences in the incidence of ONJ with the use of different types of bisphosphonates. Innovative prevention and treatment methods are also discussed. Understanding the pathogenesis and risk factors of ONJ is crucial for developing effective prevention and treatment strategies, which can significantly improve the quality of life for patients taking bisphosphonates. |
| format | Article |
| id | doaj-art-dbb89f6ed8ff44efaad390768f7cfb3f |
| institution | OA Journals |
| issn | 2414-3782 2414-3790 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Scientia Publishing House |
| record_format | Article |
| series | Juvenis Scientia |
| spelling | doaj-art-dbb89f6ed8ff44efaad390768f7cfb3f2025-08-20T02:07:41ZengScientia Publishing HouseJuvenis Scientia2414-37822414-37902025-04-01112334410.32415/jscientia_2025_11_2_33-4410.32415/jscientia_2025_11_2_33-44Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the JawPilipov, I.A.0https://orcid.org/0009-0003-0009-1256Galstian, S.G.1https://orcid.org/0000-0002-8284-1166Timofeev, E.V.2https://orcid.org/0000-0001-9607-4028Saint Petersburg State Pediatric Medical UniversitySaint Petersburg State Pediatric Medical UniversitySaint Petersburg State Pediatric Medical UniversityOsteonecrosis of the jaws (ONJ) is a severe complication associated with the administration of bisphosphonates, drugs used for the treatment of osteoporosis and metastatic bone disease. Bisphosphonates inhibit osteoclastic activity, preventing bone resorption and improving bone strength. However, these drugs can lead to ONJ, characterized by necrosis of the jaw bone tissue, inflammation of the surrounding soft tissues, chronic pain, and an increased risk of pathological fractures. The aim of this article is to provide a comprehensive review of current data on the pathogenesis, risk factors, diagnosis, treatment, and prevention of ONJ caused by the use of bisphosphonates. The article discusses the latest advancements in understanding the pathogenesis of ONJ, including the role of systemic comorbidities and oral diseases. Current diagnostic strategies for this condition are presented. Special attention is given to the differences in the incidence of ONJ with the use of different types of bisphosphonates. Innovative prevention and treatment methods are also discussed. Understanding the pathogenesis and risk factors of ONJ is crucial for developing effective prevention and treatment strategies, which can significantly improve the quality of life for patients taking bisphosphonates.https://jscientia.org/index.php/js/user/setLocale/en_US?source=/index.php/js/article/view/264?utm_source=doiosteonecrosis of the jawbisphosphonatestooth extractionosteoporosismetastatic bone diseasebone tissue necrosisprevention |
| spellingShingle | Pilipov, I.A. Galstian, S.G. Timofeev, E.V. Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the Jaw Juvenis Scientia osteonecrosis of the jaw bisphosphonates tooth extraction osteoporosis metastatic bone disease bone tissue necrosis prevention |
| title | Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the Jaw |
| title_full | Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the Jaw |
| title_fullStr | Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the Jaw |
| title_full_unstemmed | Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the Jaw |
| title_short | Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the Jaw |
| title_sort | comprehensive approach to the treatment and prevention of bisphosphonate induced osteonecrosis of the jaw |
| topic | osteonecrosis of the jaw bisphosphonates tooth extraction osteoporosis metastatic bone disease bone tissue necrosis prevention |
| url | https://jscientia.org/index.php/js/user/setLocale/en_US?source=/index.php/js/article/view/264?utm_source=doi |
| work_keys_str_mv | AT pilipovia comprehensiveapproachtothetreatmentandpreventionofbisphosphonateinducedosteonecrosisofthejaw AT galstiansg comprehensiveapproachtothetreatmentandpreventionofbisphosphonateinducedosteonecrosisofthejaw AT timofeevev comprehensiveapproachtothetreatmentandpreventionofbisphosphonateinducedosteonecrosisofthejaw |