A comparative study of ovulation induction by clomiphene citrate vs letrozole
Objectives: The present study was conducted to compare ovulation induction by clomiphene citrate and letrozole in women with ovulatory dysfunction. Methodology: In this open label comparative randomized clinical trial, patients aged 20 to 40 years with infertility diagnosed with ovulatory dysfunct...
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Barpeta Obstetrics and Gynaecological Society
2024-05-01
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| Series: | New Indian Journal of OBGYN |
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| Online Access: | https://journal.barpetaogs.co.in/pdf/10423.pdf |
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| author | Hemant Deshpande Madhukar Shinde Neha Ellath Vidya Gaikwad |
| author_facet | Hemant Deshpande Madhukar Shinde Neha Ellath Vidya Gaikwad |
| author_sort | Hemant Deshpande |
| collection | DOAJ |
| description | Objectives: The present study was conducted to compare ovulation induction by clomiphene citrate and letrozole in
women with ovulatory dysfunction. Methodology: In this open label comparative randomized clinical trial, patients
aged 20 to 40 years with infertility diagnosed with ovulatory dysfunction were treated with either letrozole or
clomiphene citrate in the Obstetrics and Gynecology OPD, of Dr. D. Y. Patil Medical College, Pune. Clomiphene
citrate (CC) was administered as 50 mg once daily for five days, then increased by 50 mg per cycle up to maximum of
150mg, if ovulation did not occur. Letrozole was administered as 2.5 mg once daily for five days, and then increased
by 2.5 mg per cycle up to maximum of 7.5 mg, if ovulation did not occur. Results: Mean age of the patients was 29.8
years and 31.44 years in letrozole and clomiphene citrate group respectively. Ovulation rate (83% vs 63%),
endometrial thickness (8.8 ± 1.5 vs 7.1 ± 1.6 mm) and pregnancy rate (63% vs 47%) was found to be significantly
higher among patients in letrozole group as compared to clomiphene citrate group. The mean numbers of follicles
were significantly lower in the letrozole group. Side effect profile was similar in letrozole and clomiphene citrate
group. Conclusion: Our findings show that individuals treated with letrozole had a better clinical outcome than those
treated with clomiphene citrate, which has a comparable adverse effect profile. |
| format | Article |
| id | doaj-art-dba1e231729d481291c33db6456cfd2c |
| institution | OA Journals |
| issn | 2454-2334 2454-2342 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Barpeta Obstetrics and Gynaecological Society |
| record_format | Article |
| series | New Indian Journal of OBGYN |
| spelling | doaj-art-dba1e231729d481291c33db6456cfd2c2025-08-20T02:16:55ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422024-05-0110242342810.21276/obgyn.2024.10.2.33A comparative study of ovulation induction by clomiphene citrate vs letrozoleHemant Deshpande0Madhukar Shinde1Neha Ellath2Vidya Gaikwad3Professor and Head of Department, Obstetrics and Gynecology, Dr. D.Y. Patil Medical College Hospital and Research Centre, Pimpri, Pune, Maharashtra, IndiaAssociate Professor, Department of Obstetrics and Gynecology, Dr. D. Y. Patil Medical College Hospital and Research Centre, Pimpri, Pune, Maharashtra, India Resident, Department of Obstetrics and Gynecology, Dr. D. Y. Patil Medical College Hospital and Research Centre, Pimpri, Pune, Maharashtra, IndiaProfessor and Head of Unit, Department of Obstetrics and Gynecology, Dr. D. Y. Patil Medical College Hospital and Research Centre, Pimpri, Pune, Maharashtra, IndiaObjectives: The present study was conducted to compare ovulation induction by clomiphene citrate and letrozole in women with ovulatory dysfunction. Methodology: In this open label comparative randomized clinical trial, patients aged 20 to 40 years with infertility diagnosed with ovulatory dysfunction were treated with either letrozole or clomiphene citrate in the Obstetrics and Gynecology OPD, of Dr. D. Y. Patil Medical College, Pune. Clomiphene citrate (CC) was administered as 50 mg once daily for five days, then increased by 50 mg per cycle up to maximum of 150mg, if ovulation did not occur. Letrozole was administered as 2.5 mg once daily for five days, and then increased by 2.5 mg per cycle up to maximum of 7.5 mg, if ovulation did not occur. Results: Mean age of the patients was 29.8 years and 31.44 years in letrozole and clomiphene citrate group respectively. Ovulation rate (83% vs 63%), endometrial thickness (8.8 ± 1.5 vs 7.1 ± 1.6 mm) and pregnancy rate (63% vs 47%) was found to be significantly higher among patients in letrozole group as compared to clomiphene citrate group. The mean numbers of follicles were significantly lower in the letrozole group. Side effect profile was similar in letrozole and clomiphene citrate group. Conclusion: Our findings show that individuals treated with letrozole had a better clinical outcome than those treated with clomiphene citrate, which has a comparable adverse effect profile.https://journal.barpetaogs.co.in/pdf/10423.pdfletrozoleclomiphene citrateinfertilityovulation induction |
| spellingShingle | Hemant Deshpande Madhukar Shinde Neha Ellath Vidya Gaikwad A comparative study of ovulation induction by clomiphene citrate vs letrozole New Indian Journal of OBGYN letrozole clomiphene citrate infertility ovulation induction |
| title | A comparative study of ovulation induction by clomiphene citrate vs letrozole |
| title_full | A comparative study of ovulation induction by clomiphene citrate vs letrozole |
| title_fullStr | A comparative study of ovulation induction by clomiphene citrate vs letrozole |
| title_full_unstemmed | A comparative study of ovulation induction by clomiphene citrate vs letrozole |
| title_short | A comparative study of ovulation induction by clomiphene citrate vs letrozole |
| title_sort | comparative study of ovulation induction by clomiphene citrate vs letrozole |
| topic | letrozole clomiphene citrate infertility ovulation induction |
| url | https://journal.barpetaogs.co.in/pdf/10423.pdf |
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