Universal fibroblasts across tissues can differentiate into niche cells for hematopoietic stem cells

Universal fibroblasts across tissues can differentiate into niche cells for hematopoietic stem cells

Summary: Hematopoietic stem cells (HSCs) generating all blood cells are maintained by their niche cells, termed CXCL12-abundant reticular (CAR) cells, which strongly overlap with leptin-receptor-expressing (LepR+) cells in the bone marrow. A meta-analysis of single-cell RNA sequencing datasets acros...

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Bibliographic Details
Main Authors: Kei Higaki, Shota Aiba, Takashi Shimoyama, Yoshiki Omatsu, Takashi Nagasawa
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003912
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