N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease Research
Alzheimer’s disease (AD) is an incurable neurodegenerative disorder that debilitates an overwhelming number of people in the aging population worldwide. The aggregated forms of the amyloid beta (Aβ) peptide play an important role in the onset of AD. Small molecules that can bind to Aβ are useful for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/11/2471 |
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| author | Citlali Gutiérrez Liang Sun Yiran Huang Kai Gui Karna Terpstra Liviu M. Mirica |
| author_facet | Citlali Gutiérrez Liang Sun Yiran Huang Kai Gui Karna Terpstra Liviu M. Mirica |
| author_sort | Citlali Gutiérrez |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is an incurable neurodegenerative disorder that debilitates an overwhelming number of people in the aging population worldwide. The aggregated forms of the amyloid beta (Aβ) peptide play an important role in the onset of AD. Small molecules that can bind to Aβ are useful for in vitro assays, in vivo imaging, and in therapeutic research. Herein, a series of compounds that can target Aβ aggregates and inhibit their formation were developed. The interaction of several compounds with the Aβ peptide was found to modulate the formation of aggregates. These N-alkylamino stilbene compounds offer selectivity toward Aβ species against other in situ proteins and have potential for aiding the development of soluble Aβ aggregate selective AD probes. |
| format | Article |
| id | doaj-art-db8dbdacd55d450b8f06436de3d5d38a |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-db8dbdacd55d450b8f06436de3d5d38a2025-08-20T03:11:22ZengMDPI AGMolecules1420-30492025-06-013011247110.3390/molecules30112471N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease ResearchCitlali Gutiérrez0Liang Sun1Yiran Huang2Kai Gui3Karna Terpstra4Liviu M. Mirica5Department of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, IL 61801, USADepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, IL 61801, USADepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, IL 61801, USADepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, IL 61801, USADepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, IL 61801, USADepartment of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Avenue, Urbana, IL 61801, USAAlzheimer’s disease (AD) is an incurable neurodegenerative disorder that debilitates an overwhelming number of people in the aging population worldwide. The aggregated forms of the amyloid beta (Aβ) peptide play an important role in the onset of AD. Small molecules that can bind to Aβ are useful for in vitro assays, in vivo imaging, and in therapeutic research. Herein, a series of compounds that can target Aβ aggregates and inhibit their formation were developed. The interaction of several compounds with the Aβ peptide was found to modulate the formation of aggregates. These N-alkylamino stilbene compounds offer selectivity toward Aβ species against other in situ proteins and have potential for aiding the development of soluble Aβ aggregate selective AD probes.https://www.mdpi.com/1420-3049/30/11/2471Alzheimer’s diseasebeta-amyloidchemical toolsAβ probesprotein aggregation |
| spellingShingle | Citlali Gutiérrez Liang Sun Yiran Huang Kai Gui Karna Terpstra Liviu M. Mirica N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease Research Molecules Alzheimer’s disease beta-amyloid chemical tools Aβ probes protein aggregation |
| title | N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease Research |
| title_full | N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease Research |
| title_fullStr | N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease Research |
| title_full_unstemmed | N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease Research |
| title_short | N-Alkylamino Stilbene Compounds as Amyloid β Inhibitors for Alzheimer’s Disease Research |
| title_sort | n alkylamino stilbene compounds as amyloid β inhibitors for alzheimer s disease research |
| topic | Alzheimer’s disease beta-amyloid chemical tools Aβ probes protein aggregation |
| url | https://www.mdpi.com/1420-3049/30/11/2471 |
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