New insights into the role of cellular senescence and rheumatic diseases
Rheumatic disease is a chronic inflammatory disease that imposes significant societal and economic burdens. Accumulating evidence has demonstrated that cellular senescence plays an important role in inflammation-induced rheumatic diseases. Due to the lack of effective therapies, there is an urgent n...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557402/full |
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| author | Jianting Wen Jianting Wen Jianting Wen Jian Liu Jian Liu Jian Liu Lei Wan Lei Wan Lei Wan Fanfan Wang Fanfan Wang |
| author_facet | Jianting Wen Jianting Wen Jianting Wen Jian Liu Jian Liu Jian Liu Lei Wan Lei Wan Lei Wan Fanfan Wang Fanfan Wang |
| author_sort | Jianting Wen |
| collection | DOAJ |
| description | Rheumatic disease is a chronic inflammatory disease that imposes significant societal and economic burdens. Accumulating evidence has demonstrated that cellular senescence plays an important role in inflammation-induced rheumatic diseases. Due to the lack of effective therapies, there is an urgent need for a deeper understanding of the etiopathogenesis of rheumatic diseases. In this review, we systematically summarized the role of cellular senescence in rheumatic diseases. We first focused on the mechanisms and hallmarks of cellular senescence, and then summarized evidence that can induce or aggravate cellular senescence, as well as related signaling pathways. Next, we discussed the mechanisms of interaction between cellular senescence and rheumatic diseases. Additionally, we focused on and elucidated the mechanisms and impacts of chondrocyte senescence and mesenchymal stem cell (MSC) senescence in osteoarthritis (OA) and systemic lupus erythematosus (SLE), respectively. Finally, we highlighted the potential of therapies targeting senescent cells in rheumatic diseases as a strategy, especially the multi-target effect of traditional Chinese medicine. |
| format | Article |
| id | doaj-art-db8a4cbb0e574c45b3f26da7cfccdf25 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-db8a4cbb0e574c45b3f26da7cfccdf252025-08-20T01:51:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15574021557402New insights into the role of cellular senescence and rheumatic diseasesJianting Wen0Jianting Wen1Jianting Wen2Jian Liu3Jian Liu4Jian Liu5Lei Wan6Lei Wan7Lei Wan8Fanfan Wang9Fanfan Wang10Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, ChinaInstitute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Modern Chinese Medicine, Department of Internal Medicine Application Foundation Research and Development, Hefei, Anhui, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, ChinaInstitute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Modern Chinese Medicine, Department of Internal Medicine Application Foundation Research and Development, Hefei, Anhui, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, ChinaInstitute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Modern Chinese Medicine, Department of Internal Medicine Application Foundation Research and Development, Hefei, Anhui, ChinaInstitute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui, ChinaAnhui Province Key Laboratory of Modern Chinese Medicine, Department of Internal Medicine Application Foundation Research and Development, Hefei, Anhui, ChinaRheumatic disease is a chronic inflammatory disease that imposes significant societal and economic burdens. Accumulating evidence has demonstrated that cellular senescence plays an important role in inflammation-induced rheumatic diseases. Due to the lack of effective therapies, there is an urgent need for a deeper understanding of the etiopathogenesis of rheumatic diseases. In this review, we systematically summarized the role of cellular senescence in rheumatic diseases. We first focused on the mechanisms and hallmarks of cellular senescence, and then summarized evidence that can induce or aggravate cellular senescence, as well as related signaling pathways. Next, we discussed the mechanisms of interaction between cellular senescence and rheumatic diseases. Additionally, we focused on and elucidated the mechanisms and impacts of chondrocyte senescence and mesenchymal stem cell (MSC) senescence in osteoarthritis (OA) and systemic lupus erythematosus (SLE), respectively. Finally, we highlighted the potential of therapies targeting senescent cells in rheumatic diseases as a strategy, especially the multi-target effect of traditional Chinese medicine.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557402/fullcellular senescencerheumatic diseaseschronic inflammationtreatment strategyTCM |
| spellingShingle | Jianting Wen Jianting Wen Jianting Wen Jian Liu Jian Liu Jian Liu Lei Wan Lei Wan Lei Wan Fanfan Wang Fanfan Wang New insights into the role of cellular senescence and rheumatic diseases Frontiers in Immunology cellular senescence rheumatic diseases chronic inflammation treatment strategy TCM |
| title | New insights into the role of cellular senescence and rheumatic diseases |
| title_full | New insights into the role of cellular senescence and rheumatic diseases |
| title_fullStr | New insights into the role of cellular senescence and rheumatic diseases |
| title_full_unstemmed | New insights into the role of cellular senescence and rheumatic diseases |
| title_short | New insights into the role of cellular senescence and rheumatic diseases |
| title_sort | new insights into the role of cellular senescence and rheumatic diseases |
| topic | cellular senescence rheumatic diseases chronic inflammation treatment strategy TCM |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557402/full |
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