C-reactive protein: the nexus between inflammation and protein misfolding diseases

C-reactive protein: the nexus between inflammation and protein misfolding diseases

C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form called pCRP. Upon interaction with activated...

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Bibliographic Details
Main Authors: Abhishek Roy, Johannes Zeller, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, James D. McFadyen, Karlheinz Peter
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
C-reactive protein
misfolded proteins
protein aggregation
neurodegenerative diseases
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612703/full
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