Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666
Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C (<b>1</b>) and D (<b>2</b>) were isolated from the marine-derived fungus <i>Aspergillus</i> sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data ana...
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MDPI AG
2025-03-01
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| author | Fangwen Jiao Tianyu Liu Kaiwei Wang Shuai Li Ruihua Jiao Wei Lin |
| author_facet | Fangwen Jiao Tianyu Liu Kaiwei Wang Shuai Li Ruihua Jiao Wei Lin |
| author_sort | Fangwen Jiao |
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| description | Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C (<b>1</b>) and D (<b>2</b>) were isolated from the marine-derived fungus <i>Aspergillus</i> sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data analyses including COSY, HSQC, HMBC, and NOESY experiments. Both isolated metabolites (<b>1</b> and <b>2</b>) exhibited significant growth inhibition against four clinically relevant bacterial strains with minimum inhibitory concentration (MIC) values of about 12.5 μΜ. Moreover, we proposed a plausible biosynthetic pathway of zopfiellamide D (<b>2</b>) in this work. |
| format | Article |
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| issn | 1420-3049 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-db8770f5f79b4aa89c0e94a874f127142025-08-20T02:17:01ZengMDPI AGMolecules1420-30492025-03-01307150210.3390/molecules30071502Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666Fangwen Jiao0Tianyu Liu1Kaiwei Wang2Shuai Li3Ruihua Jiao4Wei Lin5Department of Pathogen Biology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaDepartment of Pathogen Biology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaDepartment of Pathogen Biology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaDepartment of Pathogen Biology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, ChinaDepartment of Pathogen Biology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaTwo new decalin-tetramic acid hybrid metabolites, zopfiellamides C (<b>1</b>) and D (<b>2</b>) were isolated from the marine-derived fungus <i>Aspergillus</i> sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data analyses including COSY, HSQC, HMBC, and NOESY experiments. Both isolated metabolites (<b>1</b> and <b>2</b>) exhibited significant growth inhibition against four clinically relevant bacterial strains with minimum inhibitory concentration (MIC) values of about 12.5 μΜ. Moreover, we proposed a plausible biosynthetic pathway of zopfiellamide D (<b>2</b>) in this work.https://www.mdpi.com/1420-3049/30/7/1502tetramic acidzopfiellamidesmarine fungus<i>Aspergillus</i> sp.structure elucidationantibacterial activity |
| spellingShingle | Fangwen Jiao Tianyu Liu Kaiwei Wang Shuai Li Ruihua Jiao Wei Lin Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666 Molecules tetramic acid zopfiellamides marine fungus <i>Aspergillus</i> sp. structure elucidation antibacterial activity |
| title | Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666 |
| title_full | Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666 |
| title_fullStr | Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666 |
| title_full_unstemmed | Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666 |
| title_short | Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666 |
| title_sort | zopfiellamides c and d new decalin type tetramic acid derivatives from the marine derived fungus i aspergillus i sp nf666 |
| topic | tetramic acid zopfiellamides marine fungus <i>Aspergillus</i> sp. structure elucidation antibacterial activity |
| url | https://www.mdpi.com/1420-3049/30/7/1502 |
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