Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes
2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide ligand with a series of transition metal complexes has been synthesized via two routes: microwave irradiation and conventional heating method. Microwave irritation method happened to be the efficient and versatile route for the synthesis of these...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/404617 |
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| author | Rayees Ahmad Shiekh Maqsood Ahmad Malik Shaeel Ahmed Al-Thabaiti Mohmmad Younus Wani Arshid Nabi |
| author_facet | Rayees Ahmad Shiekh Maqsood Ahmad Malik Shaeel Ahmed Al-Thabaiti Mohmmad Younus Wani Arshid Nabi |
| author_sort | Rayees Ahmad Shiekh |
| collection | DOAJ |
| description | 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide ligand with a series of transition metal complexes has been synthesized via two routes: microwave irradiation and conventional heating method. Microwave irritation method happened to be the efficient and versatile route for the synthesis of these metal complexes. These complexes were found to have the general composition M(L)Cl2/M(L)(CH3COO)2 (where M = Cu(II), Co(II), Ni(II), and L = ligand). Different physical and spectroscopic techniques were used to investigate the structural features of the synthesized compounds, which supported an octahedral geometry for these complexes. In vitro antifungal activity of the ligand and its metal complexes revealed that the metal complexes are highly active compared to the standard drug. Metal complexes showed enhanced activity compared to the ligand, which is an important step towards the designing of antifungal drug candidates. |
| format | Article |
| id | doaj-art-db816b2dd6194f27a7e7292d8d03e09a |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-db816b2dd6194f27a7e7292d8d03e09a2025-02-03T06:04:58ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/404617404617Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal ComplexesRayees Ahmad Shiekh0Maqsood Ahmad Malik1Shaeel Ahmed Al-Thabaiti2Mohmmad Younus Wani3Arshid Nabi4Biomaterial Research Unit, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, MalaysiaDepartment of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartamento de Quımica, FCTUC, Universidade de Coimbra, Rua Larga, 3004-535 Coimbra, PortugalSchool of Pharmaceutical Sciences, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, Punjab-144411, India2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide ligand with a series of transition metal complexes has been synthesized via two routes: microwave irradiation and conventional heating method. Microwave irritation method happened to be the efficient and versatile route for the synthesis of these metal complexes. These complexes were found to have the general composition M(L)Cl2/M(L)(CH3COO)2 (where M = Cu(II), Co(II), Ni(II), and L = ligand). Different physical and spectroscopic techniques were used to investigate the structural features of the synthesized compounds, which supported an octahedral geometry for these complexes. In vitro antifungal activity of the ligand and its metal complexes revealed that the metal complexes are highly active compared to the standard drug. Metal complexes showed enhanced activity compared to the ligand, which is an important step towards the designing of antifungal drug candidates.http://dx.doi.org/10.1155/2014/404617 |
| spellingShingle | Rayees Ahmad Shiekh Maqsood Ahmad Malik Shaeel Ahmed Al-Thabaiti Mohmmad Younus Wani Arshid Nabi Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes The Scientific World Journal |
| title | Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes |
| title_full | Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes |
| title_fullStr | Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes |
| title_full_unstemmed | Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes |
| title_short | Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes |
| title_sort | microwave assisted synthesis spectral and antifungal studies of 2 phenyl n n bis pyridin 4 ylcarbonyl butanediamide ligand and its metal complexes |
| url | http://dx.doi.org/10.1155/2014/404617 |
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