Enhanced antibiotic release and biocompatibility with simultaneous addition of N-acetylcysteine and vancomycin to bone cement: a potential replacement for high-dose antibiotic-loaded bone cement

Enhanced antibiotic release and biocompatibility with simultaneous addition of N-acetylcysteine and vancomycin to bone cement: a potential replacement for high-dose antibiotic-loaded bone cement

Abstract Background Antibiotic-loaded bone cement (ALBC) is crucial for treating orthopedic infections, but its use is limited by suboptimal antibiotic release patterns and potential toxicity. This study explores the dual addition of N-acetylcysteine (NAC) and vancomycin to polymethylmethacrylate (P...

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Bibliographic Details
Main Authors: Tzu-Hao Tseng, Chih-Hao Chang, Chien-Lin Chen, Hongsen Chiang, Jyh-Horng Wang, Tai-Horng Young
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Antibiotic-loaded bone cement
Vancomycin
N-acetylcysteine
PMMA
Cytotoxicity
Online Access:https://doi.org/10.1186/s13018-025-05637-y
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