Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Abstract Proteolysis‐targeting chimeras (PROTACs) degrade target proteins through the ubiquitin‐proteasome system. To date, PROTACs are primarily used to treat various diseases; however, they have not been applied in regenerative therapy. Herein, this work introduces MDM2‐targeting PROTACs customize...

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Bibliographic Details
Main Authors: Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
bone
MDM2
osteoporosis
PROTAC
regenerative medicine
Online Access:https://doi.org/10.1002/advs.202415626
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