TREM-1-Linked Inflammatory Cargo in SARS-CoV-2-Stimulated Macrophage Extracellular Vesicles Drives Cellular Senescence and Impairs Antibacterial Defense

TREM-1-Linked Inflammatory Cargo in SARS-CoV-2-Stimulated Macrophage Extracellular Vesicles Drives Cellular Senescence and Impairs Antibacterial Defense

The COVID-19 pandemic, caused by SARS-CoV-2, has significantly affected global health, with severe inflammatory responses leading to tissue damage and persistent symptoms. Macrophage-derived extracellular vesicles (EVs) are involved in the modulation of immune responses, but their involvement in SAR...

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Bibliographic Details
Main Authors: Pedro V. da Silva-Neto, Jonatan C. S. de Carvalho, Diana M. Toro, Bianca T. M. Oliveira, Juçara G. Cominal, Ricardo C. Castro, Maria A. Almeida, Cibele M. Prado, Eurico Arruda, Fabiani G. Frantz, Ana P. Ramos, Pietro Ciancaglini, Ronaldo B. Martins, Juliano C. da Silveira, Fausto Almeida, Kelen C. R. Malmegrim, Carlos A. Sorgi
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Viruses
Subjects:
SARS-CoV-2
macrophages
extracellular vesicles
TREM-1
SASP
Online Access:https://www.mdpi.com/1999-4915/17/5/610
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