Association between triglyceride-glucose index and cataract among outpatient US adults
BackgroundAlthough numerous studies have associated a higher TyG index with various diseases, there is limited research on its potential link to cataract. This study seeks to investigate the relationship between the TyG index and cataract in the outpatient adult population in the United States.Metho...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1523711/full |
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| author | Qi Jin Jin Huang Liyun Gao Jianmin Zhu |
| author_facet | Qi Jin Jin Huang Liyun Gao Jianmin Zhu |
| author_sort | Qi Jin |
| collection | DOAJ |
| description | BackgroundAlthough numerous studies have associated a higher TyG index with various diseases, there is limited research on its potential link to cataract. This study seeks to investigate the relationship between the TyG index and cataract in the outpatient adult population in the United States.MethodsOur study used NHANES data from the 1999–2008 cycles. We applied weighted multivariate logistic regression to investigate the relationship between the TyG index and cataract in the United States and conducted subgroup analysis to assess the robustness of these associations across different populations.ResultsAmong 5,433 adults [2,699 (46.8%) male; 2,734 (53.2%) female], 1,038 (15.4%) had cataract. A fully adjusted model (i.e., model 2) showed that the highest quartile array of TyG index (Quartile IV) was positively associated with a higher risk of cataract among men (OR = 1.63 (1.10–2.43), p = 0.016). No difference was found in the female population.ConclusionOur research reveals that the highest quartile array of TyG index (Quartile IV) is associated with a higher risk of cataract among men. This suggests that elevated levels of this index may contribute to the likelihood of developing cataracts, emphasizing the need to consider this metabolic parameter when assessing eye health in male participants. |
| format | Article |
| id | doaj-art-db5ef9d5efee48d09ccd689b4198d8e5 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-db5ef9d5efee48d09ccd689b4198d8e52025-08-20T02:34:12ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-05-011210.3389/fmed.2025.15237111523711Association between triglyceride-glucose index and cataract among outpatient US adultsQi Jin0Jin Huang1Liyun Gao2Jianmin Zhu3The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Zhejiang, ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, ChinaThe First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Zhejiang, ChinaThe First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Zhejiang, ChinaBackgroundAlthough numerous studies have associated a higher TyG index with various diseases, there is limited research on its potential link to cataract. This study seeks to investigate the relationship between the TyG index and cataract in the outpatient adult population in the United States.MethodsOur study used NHANES data from the 1999–2008 cycles. We applied weighted multivariate logistic regression to investigate the relationship between the TyG index and cataract in the United States and conducted subgroup analysis to assess the robustness of these associations across different populations.ResultsAmong 5,433 adults [2,699 (46.8%) male; 2,734 (53.2%) female], 1,038 (15.4%) had cataract. A fully adjusted model (i.e., model 2) showed that the highest quartile array of TyG index (Quartile IV) was positively associated with a higher risk of cataract among men (OR = 1.63 (1.10–2.43), p = 0.016). No difference was found in the female population.ConclusionOur research reveals that the highest quartile array of TyG index (Quartile IV) is associated with a higher risk of cataract among men. This suggests that elevated levels of this index may contribute to the likelihood of developing cataracts, emphasizing the need to consider this metabolic parameter when assessing eye health in male participants.https://www.frontiersin.org/articles/10.3389/fmed.2025.1523711/fullcataracttriglyceride-glucose (TyG) indexcross-sectional studyNational Health and Nutrition Examination Survey (NHANES)outpatient US adults |
| spellingShingle | Qi Jin Jin Huang Liyun Gao Jianmin Zhu Association between triglyceride-glucose index and cataract among outpatient US adults Frontiers in Medicine cataract triglyceride-glucose (TyG) index cross-sectional study National Health and Nutrition Examination Survey (NHANES) outpatient US adults |
| title | Association between triglyceride-glucose index and cataract among outpatient US adults |
| title_full | Association between triglyceride-glucose index and cataract among outpatient US adults |
| title_fullStr | Association between triglyceride-glucose index and cataract among outpatient US adults |
| title_full_unstemmed | Association between triglyceride-glucose index and cataract among outpatient US adults |
| title_short | Association between triglyceride-glucose index and cataract among outpatient US adults |
| title_sort | association between triglyceride glucose index and cataract among outpatient us adults |
| topic | cataract triglyceride-glucose (TyG) index cross-sectional study National Health and Nutrition Examination Survey (NHANES) outpatient US adults |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1523711/full |
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