Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome
Among the numerous emerging biomarkers, high-sensitivity C-reactive protein (hsCRP) and growth-differentiation factor-15 (GDF-15) have received widespread interest, with their potential role as predictors of cardiovascular risk. The concentrations of inflammatory biomarkers, however, are influenced,...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/929536 |
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| author | Alberto Dominguez-Rodriguez Pedro Abreu-Gonzalez Idaira F. Hernandez-Baldomero Pablo Avanzas Francisco Bosa-Ojeda |
| author_facet | Alberto Dominguez-Rodriguez Pedro Abreu-Gonzalez Idaira F. Hernandez-Baldomero Pablo Avanzas Francisco Bosa-Ojeda |
| author_sort | Alberto Dominguez-Rodriguez |
| collection | DOAJ |
| description | Among the numerous emerging biomarkers, high-sensitivity C-reactive protein (hsCRP) and growth-differentiation factor-15 (GDF-15) have received widespread interest, with their potential role as predictors of cardiovascular risk. The concentrations of inflammatory biomarkers, however, are influenced, among others, by physiological variations, which are the natural, within-individual variation occurring over time. The aims of our study are: (a) to describe the changes in hsCRP and GDF-15 levels over a period of time and after an episode of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and (b) to examine whether the rate of change in hsCRP and GDF-15 after the acute event is associated with long-term major cardiovascular adverse events (MACE). Two hundred and Fifty five NSTE-ACS patients were included in the study. We measured hsCRP and GDF-15 concentrations, at admission and again 36 months after admission (end of the follow-up period). The present study shows that the change of hsCRP levels, measured after 36 months, does not predict MACE in NSTEACS-patients. However, the level of GDF-15 measured, after 36 months, was a stronger predictor of MACE, in comparison to the acute unstable phase. |
| format | Article |
| id | doaj-art-db598911585e4d4188036ea7f1d3321e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-db598911585e4d4188036ea7f1d3321e2025-02-03T00:59:50ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/929536929536Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary SyndromeAlberto Dominguez-Rodriguez0Pedro Abreu-Gonzalez1Idaira F. Hernandez-Baldomero2Pablo Avanzas3Francisco Bosa-Ojeda4Department of Cardiology, Hospital Universitario de Canarias, Ofra s/n La Cuesta, 38320 Tenerife, SpainInstituto Universitario de Tecnología Biomédicas, Ofra s/n La Cuesta, 38320 Tenerife, SpainDepartment of Cardiology, Hospital Universitario de Canarias, Ofra s/n La Cuesta, 38320 Tenerife, SpainHospital Universitario Central de Asturias, Area del Corazón, 33006 Oviedo, SpainDepartment of Cardiology, Hospital Universitario de Canarias, Ofra s/n La Cuesta, 38320 Tenerife, SpainAmong the numerous emerging biomarkers, high-sensitivity C-reactive protein (hsCRP) and growth-differentiation factor-15 (GDF-15) have received widespread interest, with their potential role as predictors of cardiovascular risk. The concentrations of inflammatory biomarkers, however, are influenced, among others, by physiological variations, which are the natural, within-individual variation occurring over time. The aims of our study are: (a) to describe the changes in hsCRP and GDF-15 levels over a period of time and after an episode of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and (b) to examine whether the rate of change in hsCRP and GDF-15 after the acute event is associated with long-term major cardiovascular adverse events (MACE). Two hundred and Fifty five NSTE-ACS patients were included in the study. We measured hsCRP and GDF-15 concentrations, at admission and again 36 months after admission (end of the follow-up period). The present study shows that the change of hsCRP levels, measured after 36 months, does not predict MACE in NSTEACS-patients. However, the level of GDF-15 measured, after 36 months, was a stronger predictor of MACE, in comparison to the acute unstable phase.http://dx.doi.org/10.1155/2014/929536 |
| spellingShingle | Alberto Dominguez-Rodriguez Pedro Abreu-Gonzalez Idaira F. Hernandez-Baldomero Pablo Avanzas Francisco Bosa-Ojeda Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome Mediators of Inflammation |
| title | Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome |
| title_full | Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome |
| title_fullStr | Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome |
| title_full_unstemmed | Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome |
| title_short | Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome |
| title_sort | change in growth differentiation factor 15 but not c reactive protein independently predicts major cardiac events in patients with non st elevation acute coronary syndrome |
| url | http://dx.doi.org/10.1155/2014/929536 |
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