Combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiter
Abstract Fine‐needle aspiration cytology and imaging examinations are commonly used diagnostic tools for papillary thyroid carcinoma (PTC). However, these methods have limitations. Inflammatory proteins have the potential to serve as diagnostic and prognostic markers, as well as treatment targets. T...
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2024-09-01
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| Online Access: | https://doi.org/10.1002/imo2.14 |
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| author | Yongqin Pan Mingxi Xu Tsz Hong Chong Siping Xie Kunsong Huang Guanghao Wang Yuhua Ma Jinyi Li Wah Yang |
| author_facet | Yongqin Pan Mingxi Xu Tsz Hong Chong Siping Xie Kunsong Huang Guanghao Wang Yuhua Ma Jinyi Li Wah Yang |
| author_sort | Yongqin Pan |
| collection | DOAJ |
| description | Abstract Fine‐needle aspiration cytology and imaging examinations are commonly used diagnostic tools for papillary thyroid carcinoma (PTC). However, these methods have limitations. Inflammatory proteins have the potential to serve as diagnostic and prognostic markers, as well as treatment targets. The expression profile and diagnosis effect of inflammatory proteins in PTC are not well understood. Here, 18 healthy volunteers (as healthy control), 12 patients with nodular goiter, and 34 patients with PTC were collected to analyze serum inflammatory proteins by proximity extension assay. Receiver operating characteristic curve analysis was used to evaluate the diagnostic potential of differential expression of proteins via the area under the curve (AUC) analysis. A total of 36 differentially expressed inflammatory proteins were found among PTC, nodular goiter, and healthy control. The combination diagnosis derived from the logistic regression analysis exhibited promising diagnostic capabilities in distinguishing nodular goiter from healthy control (AUC = 0.88), distinguishing PTC from healthy control (AUC = 0.89), and distinguishing PTC from nodular goiter (AUC = 0.87). Whereas the combination diagnosis derived from the least absolute shrinkage and selection operator (LASSO) exhibited promising diagnostic capabilities in distinguishing nodular goiter from healthy control (AUC = 0.92), distinguishing PTC from healthy control (AUC = 0.93), and distinguishing PTC from nodular goiter (AUC = 0.93). Overall, this study offers potential biomarkers for distinguishing between PTC and nodular goiter in clinical practice. The combination derived from the LASSO algorithm outperforms logistic regression. |
| format | Article |
| id | doaj-art-db54608ec128432b90ca84f20f243435 |
| institution | Kabale University |
| issn | 2996-9506 2996-9514 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMetaOmics |
| spelling | doaj-art-db54608ec128432b90ca84f20f2434352025-01-31T16:15:20ZengWileyiMetaOmics2996-95062996-95142024-09-0111n/an/a10.1002/imo2.14Combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiterYongqin Pan0Mingxi Xu1Tsz Hong Chong2Siping Xie3Kunsong Huang4Guanghao Wang5Yuhua Ma6Jinyi Li7Wah Yang8Department of Thyroid Surgery The First Affiliated Hospital of Jinan University Guangzhou ChinaDepartment of Thyroid Surgery The First Affiliated Hospital of Jinan University Guangzhou ChinaDepartment of Thyroid Surgery The First Affiliated Hospital of Jinan University Guangzhou ChinaMedical Record Room The First Affiliated Hospital of Jinan University Guangzhou ChinaDepartment of Thyroid Surgery The First Affiliated Hospital of Jinan University Guangzhou ChinaDepartment of Thyroid Surgery The First Affiliated Hospital of Jinan University Guangzhou ChinaDepartment of Thyroid Surgery The First Affiliated Hospital of Jinan University Guangzhou ChinaDepartment of Thyroid Surgery The First Affiliated Hospital of Jinan University Guangzhou ChinaDepartment of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan University Guangzhou ChinaAbstract Fine‐needle aspiration cytology and imaging examinations are commonly used diagnostic tools for papillary thyroid carcinoma (PTC). However, these methods have limitations. Inflammatory proteins have the potential to serve as diagnostic and prognostic markers, as well as treatment targets. The expression profile and diagnosis effect of inflammatory proteins in PTC are not well understood. Here, 18 healthy volunteers (as healthy control), 12 patients with nodular goiter, and 34 patients with PTC were collected to analyze serum inflammatory proteins by proximity extension assay. Receiver operating characteristic curve analysis was used to evaluate the diagnostic potential of differential expression of proteins via the area under the curve (AUC) analysis. A total of 36 differentially expressed inflammatory proteins were found among PTC, nodular goiter, and healthy control. The combination diagnosis derived from the logistic regression analysis exhibited promising diagnostic capabilities in distinguishing nodular goiter from healthy control (AUC = 0.88), distinguishing PTC from healthy control (AUC = 0.89), and distinguishing PTC from nodular goiter (AUC = 0.87). Whereas the combination diagnosis derived from the least absolute shrinkage and selection operator (LASSO) exhibited promising diagnostic capabilities in distinguishing nodular goiter from healthy control (AUC = 0.92), distinguishing PTC from healthy control (AUC = 0.93), and distinguishing PTC from nodular goiter (AUC = 0.93). Overall, this study offers potential biomarkers for distinguishing between PTC and nodular goiter in clinical practice. The combination derived from the LASSO algorithm outperforms logistic regression.https://doi.org/10.1002/imo2.14diagnosisnodular goiterpapillary thyroid carcinomaproximity extension assay |
| spellingShingle | Yongqin Pan Mingxi Xu Tsz Hong Chong Siping Xie Kunsong Huang Guanghao Wang Yuhua Ma Jinyi Li Wah Yang Combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiter iMetaOmics diagnosis nodular goiter papillary thyroid carcinoma proximity extension assay |
| title | Combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiter |
| title_full | Combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiter |
| title_fullStr | Combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiter |
| title_full_unstemmed | Combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiter |
| title_short | Combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiter |
| title_sort | combined detection of inflammatory proteins is beneficial for diagnosing the papillary thyroid carcinoma and nodular goiter |
| topic | diagnosis nodular goiter papillary thyroid carcinoma proximity extension assay |
| url | https://doi.org/10.1002/imo2.14 |
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