Regulatory logic of endogenous RNAi in silencing de novo genomic conflicts.
Although the biological utilities of endogenous RNAi (endo-RNAi) have been largely elusive, recent studies reveal its critical role in the non-model fruitfly Drosophila simulans to suppress selfish genes, whose unchecked activities can severely impair spermatogenesis. In particular, hairpin RNA (hpR...
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| Main Authors: | Jeffrey Vedanayagam, Ching-Jung Lin, Ranjith Papareddy, Michael Nodine, Alex S Flynt, Jiayu Wen, Eric C Lai |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-06-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010787&type=printable |
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