SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice

SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice

Abstract Nerve injury-induced changes in pain-associated genes contribute to genesis of neuropathic pain and comorbid anxiety. Phosphorylated CTD interacting factor-1 (PCIF1)-triggered N6, 2′-O-dimethyladenosine (m6Am) mRNA modification represents an additional layer of gene regulation. However, the...

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Main Authors: Yue Huang, Gan Ma, Shan Xie, Runa Wei, Ya Liu, Ying Zeng, Yaxuan Zhao, Qihui Wang, Li Yang, Huiying Huang, Lingyun Hao, Xiaotian Zhao, Hongjun Wang, Wen Shen, Stanley Sau Ching Wong, Jun-Li Cao, Yuan-Xiang Tao, Zhi-Qiang Pan
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62565-5
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