Reversible downregulation of HLA class I in adenoid cystic carcinoma

Reversible downregulation of HLA class I in adenoid cystic carcinoma

Background Adenoid cystic carcinoma (ACC) is a rare, but lethal cancer with low response rates to systemic therapies, such as cytotoxic chemotherapy and immune-checkpoint inhibitors (ICIs). Despite extensive clinical trials, no effective treatments for patients with recurrent or metastatic ACC are a...

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Main Authors: Xin Gao, Jeffrey Raizer, William C Faquin, Jong Chul Park, Thomas Denize, Ross D Merkin, Annie Li, Bianca L Gonda, Atul K Bhan, Stefan T Kaluziak, Markus D Herrmann, Yu-Chung Huang, Elizabeth M Codd, Adam von Paternos, Dawn R Mitchell, Prinjali Kalyan, Samantha E Flynn, Thuc Q Dzu, Chengzhuo Gao, Edwin Zhang, Julia J Mendel, Julia C Thierauf, Peter M Sadow, Diane Yang, Florian J Fintelmann, Jo Anne Fordham, Daniel L Faden, Lori J Wirth, A. John Iafrate
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/4/e011380.full
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https://jitc.bmj.com/content/13/4/e011380.full

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