NOD1: a metabolic modulator
Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular pattern recognition receptor that detects injury signals and initiates inflammatory responses and host defense. Furthermore, NOD1 serves as a metabolic mediator by influencing the metabolism of various tissues, including adipose...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1484829/full |
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| author | Ruobing Tang Chunguang Xie Chunguang Xie Chunguang Xie Xiyu Zhang Xiyu Zhang Xiyu Zhang |
| author_facet | Ruobing Tang Chunguang Xie Chunguang Xie Chunguang Xie Xiyu Zhang Xiyu Zhang Xiyu Zhang |
| author_sort | Ruobing Tang |
| collection | DOAJ |
| description | Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular pattern recognition receptor that detects injury signals and initiates inflammatory responses and host defense. Furthermore, NOD1 serves as a metabolic mediator by influencing the metabolism of various tissues, including adipose tissue, liver, cardiovascular tissue, pancreatic β cells, adrenal glands, and bones through diverse mechanisms. It has been discovered that activated NOD1 is associated with the pathological mechanisms of certain metabolic diseases. This review presents a comprehensive summary of the impact of NOD1 on tissue-specific metabolism. |
| format | Article |
| id | doaj-art-db454644263c40779929184b0877555d |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-db454644263c40779929184b0877555d2025-01-21T05:43:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14848291484829NOD1: a metabolic modulatorRuobing Tang0Chunguang Xie1Chunguang Xie2Chunguang Xie3Xiyu Zhang4Xiyu Zhang5Xiyu Zhang6Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaNucleotide-binding oligomerization domain 1 (NOD1) is an intracellular pattern recognition receptor that detects injury signals and initiates inflammatory responses and host defense. Furthermore, NOD1 serves as a metabolic mediator by influencing the metabolism of various tissues, including adipose tissue, liver, cardiovascular tissue, pancreatic β cells, adrenal glands, and bones through diverse mechanisms. It has been discovered that activated NOD1 is associated with the pathological mechanisms of certain metabolic diseases. This review presents a comprehensive summary of the impact of NOD1 on tissue-specific metabolism.https://www.frontiersin.org/articles/10.3389/fendo.2024.1484829/fullNOD1metabolismendocrineinflammationimmunity |
| spellingShingle | Ruobing Tang Chunguang Xie Chunguang Xie Chunguang Xie Xiyu Zhang Xiyu Zhang Xiyu Zhang NOD1: a metabolic modulator Frontiers in Endocrinology NOD1 metabolism endocrine inflammation immunity |
| title | NOD1: a metabolic modulator |
| title_full | NOD1: a metabolic modulator |
| title_fullStr | NOD1: a metabolic modulator |
| title_full_unstemmed | NOD1: a metabolic modulator |
| title_short | NOD1: a metabolic modulator |
| title_sort | nod1 a metabolic modulator |
| topic | NOD1 metabolism endocrine inflammation immunity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1484829/full |
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