The DNA-based Lassa vaccine INO-4500 confers durable protective efficacy in cynomolgus macaques against lethal Lassa fever

The DNA-based Lassa vaccine INO-4500 confers durable protective efficacy in cynomolgus macaques against lethal Lassa fever

Abstract Background We have previously developed a DNA-based vaccine, INO-4500, encoding the Lassa lineage IV glycoprotein precursor. INO-4500, when delivered with electroporation, elicited humoral and cellular responses, and conferred 100% protection in cynomolgus non-human primates. Here, we expan...

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Main Authors: Viviane M. Andrade, Kathleen Cashman, Kyle Rosenke, Eric Wilkinson, Nicole Josleyn, Ginger Lynn, Jesse Steffens, Sean Vantongeren, Jay Wells, Connie Schmaljohn, Paul Facemire, Jingjing Jiang, Jean Boyer, Aditya Patel, Friederike Feldmann, Patrick Hanley, Jamie Lovaglio, Kimberly White, Heinz Feldmann, Stephanie Ramos, Kate E. Broderick, Laurent M. Humeau, Trevor R. F. Smith
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-024-00684-8
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