Use of H1N1 strain A/PR/8/34 influenza to build a mouse model of viral respiratory sepsis

Use of H1N1 strain A/PR/8/34 influenza to build a mouse model of viral respiratory sepsis

Abstract Background Community-acquired respiratory infections are a prevalent cause of sepsis. Current animal models simulate peritoneal rather than respiratory sepsis. This study sought to appraise an influenza model for its ability to develop sepsis. Methods Twenty-four six-week-old male BALB/c mi...

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Bibliographic Details
Main Authors: Yaqing Jiao, Yuee Cai, Yilin Zhang, Ka-Tim Choy, Ka-Man Cheng, John M. Nicholls, Pui-Kin Lam, Hui-Ling Yen, Timothy H. Rainer
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Laboratory Animal Research
Subjects:
Influenza virus
Mouse model
Organ dysfunction
Viral respiratory sepsis
Online Access:https://doi.org/10.1186/s42826-025-00248-4
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