Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines
The hydrolysis of isatin aldazine 4a–d afforded the unexpected 3,3′-(hydrazine-1,2-diylidene)bis(indolin-2-one) (5) and 1,2-di(arylidene)hydrazines 6a–d through dual hydrolysis of 4a–d. A mechanism to explain the formation of 5 and 6a–d was proposed. In addition, the hydrazinolysis of 4a–d yielded...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/826489 |
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| author | Hany S. Ibrahim Soha R. Abdelhadi Hatem A. Abdel-Aziz |
| author_facet | Hany S. Ibrahim Soha R. Abdelhadi Hatem A. Abdel-Aziz |
| author_sort | Hany S. Ibrahim |
| collection | DOAJ |
| description | The hydrolysis of isatin aldazine 4a–d afforded the unexpected 3,3′-(hydrazine-1,2-diylidene)bis(indolin-2-one) (5) and 1,2-di(arylidene)hydrazines 6a–d through dual hydrolysis of 4a–d. A mechanism to explain the formation of 5 and 6a–d was proposed. In addition, the hydrazinolysis of 4a–d yielded 3-hydrazonoindolin-2-one (2) and 1,2-di(arylidene)hydrazines 6a–d instead of hydrazones 17a–d, while hydrazinolysis of isatin ketazine 5 gave the expected 3-hydrazonoindolin-2-one (2). These results indicated the ability of the title compounds for unusual hydrolysis and hydrazinolysis reactions. |
| format | Article |
| id | doaj-art-db3d41736f634fe3a3e419db2ec7ee67 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-db3d41736f634fe3a3e419db2ec7ee672025-02-03T05:46:50ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/826489826489Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and KetazinesHany S. Ibrahim0Soha R. Abdelhadi1Hatem A. Abdel-Aziz2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, EgyptDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, EgyptDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaThe hydrolysis of isatin aldazine 4a–d afforded the unexpected 3,3′-(hydrazine-1,2-diylidene)bis(indolin-2-one) (5) and 1,2-di(arylidene)hydrazines 6a–d through dual hydrolysis of 4a–d. A mechanism to explain the formation of 5 and 6a–d was proposed. In addition, the hydrazinolysis of 4a–d yielded 3-hydrazonoindolin-2-one (2) and 1,2-di(arylidene)hydrazines 6a–d instead of hydrazones 17a–d, while hydrazinolysis of isatin ketazine 5 gave the expected 3-hydrazonoindolin-2-one (2). These results indicated the ability of the title compounds for unusual hydrolysis and hydrazinolysis reactions.http://dx.doi.org/10.1155/2015/826489 |
| spellingShingle | Hany S. Ibrahim Soha R. Abdelhadi Hatem A. Abdel-Aziz Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines Journal of Chemistry |
| title | Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines |
| title_full | Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines |
| title_fullStr | Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines |
| title_full_unstemmed | Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines |
| title_short | Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines |
| title_sort | hydrolysis and hydrazinolysis of isatin based ald and ketazines |
| url | http://dx.doi.org/10.1155/2015/826489 |
| work_keys_str_mv | AT hanysibrahim hydrolysisandhydrazinolysisofisatinbasedaldandketazines AT soharabdelhadi hydrolysisandhydrazinolysisofisatinbasedaldandketazines AT hatemaabdelaziz hydrolysisandhydrazinolysisofisatinbasedaldandketazines |