Investigation of the combined effects of cannabidiol plus naltrexone on alcohol craving in alcohol dependence: study protocol of a phase II randomised, double-blind, placebo-controlled, parallel-group trial – ICONICplus Trial

Investigation of the combined effects of cannabidiol plus naltrexone on alcohol craving in alcohol dependence: study protocol of a phase II randomised, double-blind, placebo-controlled, parallel-group trial – ICONICplus Trial

Introduction Alcohol dependence (AD) is highly prevalent and has severe consequences on health and quality of life. However, the efficacy of approved pharmacotherapies such as naltrexone (NTX) remains limited, highlighting the need for novel pharmacotherapeutic approaches. Cannabidiol (CBD) is a pro...

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Main Authors: Falk Kiefer, Christina Klose, Bettina C Thomas, Sabine Vollstaedt-Klein, Marietta Kirchner, Anne Koopmann, Bernd Lenz, Patrick Bach, Sina Vetter, Julia Weinberg, Paul Thalmann, Marlen Pfisterer, Torsten Kölsch, Selma Oesterle, Tobias Link
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/8/e106348.full
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