Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report
Xinxin Wo, Xiaoyan Yu, Lingling Miao, Yushan Mao, Keke Tang Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People’s Republic of ChinaCorrespondence: Keke Tang, Department of Endocrinology, The First Affiliated Hospital of Ningbo University...
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Dove Medical Press
2025-01-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| author | Wo X Yu X Miao L Mao Y Tang K |
| author_facet | Wo X Yu X Miao L Mao Y Tang K |
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| description | Xinxin Wo, Xiaoyan Yu, Lingling Miao, Yushan Mao, Keke Tang Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People’s Republic of ChinaCorrespondence: Keke Tang, Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People’s Republic of China, Email lcyxtkk@126.comPurpose: Klinefelter’s syndrome (KS) is the most common sex chromosome disorder in the male population and is characterized by the presence of one or more X chromosomes. Studies have reported that the proportion of KS patients with diabetes is not low. It is also not uncommon for diabetes patients with poorly controlled blood glucose to have a transient mild increase in their carcinoembryonic antigen (CEA) levels. This study reports the case of Diabetic ketoacidosis (DKA) concurrently with a significant increase in CEA levels (reaching 40.8 ng/mL) in patients with KS.Methods: This middle-aged KS patient was immediately treated for DKA upon admission. A series of exams were performed to exclude the possibility of malignant tumors, and the patient’s glucose and CEA levels were closely monitored.Results: After excluding the possibility of malignant tumors, the patient’s CEA level gradually decreased to normal after good glycemic control.Conclusion: This is the first report describing significant increases in CEA levels in KS patients with diabetes, which is of great clinical significance for the treatment of diabetes patients.Keywords: diabetic ketoacidosis, hyperglycemia, Klinefelter’s syndrome, carcinoembryonic antigen |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
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| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj-art-db2701d0ac2a4d3a96d5a6a224b0f14d2025-01-28T17:53:33ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072025-01-01Volume 1823323699676Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case ReportWo XYu XMiao LMao YTang KXinxin Wo, Xiaoyan Yu, Lingling Miao, Yushan Mao, Keke Tang Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People’s Republic of ChinaCorrespondence: Keke Tang, Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People’s Republic of China, Email lcyxtkk@126.comPurpose: Klinefelter’s syndrome (KS) is the most common sex chromosome disorder in the male population and is characterized by the presence of one or more X chromosomes. Studies have reported that the proportion of KS patients with diabetes is not low. It is also not uncommon for diabetes patients with poorly controlled blood glucose to have a transient mild increase in their carcinoembryonic antigen (CEA) levels. This study reports the case of Diabetic ketoacidosis (DKA) concurrently with a significant increase in CEA levels (reaching 40.8 ng/mL) in patients with KS.Methods: This middle-aged KS patient was immediately treated for DKA upon admission. A series of exams were performed to exclude the possibility of malignant tumors, and the patient’s glucose and CEA levels were closely monitored.Results: After excluding the possibility of malignant tumors, the patient’s CEA level gradually decreased to normal after good glycemic control.Conclusion: This is the first report describing significant increases in CEA levels in KS patients with diabetes, which is of great clinical significance for the treatment of diabetes patients.Keywords: diabetic ketoacidosis, hyperglycemia, Klinefelter’s syndrome, carcinoembryonic antigenhttps://www.dovepress.com/diabetic-ketoacidosis-in-klinefelter-syndrome-sans-malignancy-with-unu-peer-reviewed-fulltext-article-DMSOdiabetic ketoacidosis， hyperglycemia， klinefelter's syndrome， carcinoembryonic antigen |
| spellingShingle | Wo X Yu X Miao L Mao Y Tang K Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report Diabetes, Metabolic Syndrome and Obesity diabetic ketoacidosis， hyperglycemia， klinefelter's syndrome， carcinoembryonic antigen |
| title | Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report |
| title_full | Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report |
| title_fullStr | Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report |
| title_full_unstemmed | Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report |
| title_short | Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report |
| title_sort | diabetic ketoacidosis in klinefelter syndrome sans malignancy with unusually elevated levels of cea a case report |
| topic | diabetic ketoacidosis， hyperglycemia， klinefelter's syndrome， carcinoembryonic antigen |
| url | https://www.dovepress.com/diabetic-ketoacidosis-in-klinefelter-syndrome-sans-malignancy-with-unu-peer-reviewed-fulltext-article-DMSO |
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