Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
Oral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of interleukin-37 (IL-37) on oral cancer and its...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-05-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1173 |
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| _version_ | 1850236903671988224 |
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| author | Fang Jing Li Kunshan Zhang Liyuan Zhang Ying Wang Yifan Zhang Jing |
| author_facet | Fang Jing Li Kunshan Zhang Liyuan Zhang Ying Wang Yifan Zhang Jing |
| author_sort | Fang Jing |
| collection | DOAJ |
| description | Oral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of interleukin-37 (IL-37) on oral cancer and its underlying mechanisms. Two oral cancer cell lines, HN13 and HSC-6, were employed in the study. Our findings reveal that IL-37 markedly inhibits cell viability and induces apoptosis in oral cancer cells. IL-37 attenuates the proliferation of oral cancer cells induced by lipopolysaccharide and tumor necrosis factor-alpha, while knockdown of IL-37 exacerbates this induction. Furthermore, IL-37 demonstrates anti-inflammatory effects on oral cancer cells. The modulation of inflammation, proliferation, apoptosis, and migration by IL-37 is mediated through the STAT3 pathway. The outcomes of this study contribute valuable insights to a deeper understanding of oral cancer pathogenesis and pave the way for the development of novel drugs for the treatment of this disease. |
| format | Article |
| id | doaj-art-db19a545c7b6445fa05af3b8c816c990 |
| institution | OA Journals |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-db19a545c7b6445fa05af3b8c816c9902025-08-20T02:01:53ZengDe GruyterOpen Medicine2391-54632025-05-0120113132010.1515/med-2025-1173Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3Fang Jing0Li Kunshan1Zhang Liyuan2Zhang Ying3Wang Yifan4Zhang Jing5Endoscopy Clinic, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao, Hebei, 066000, ChinaDepartment of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, ChinaDepartment of Stomatology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao, Hebei, 066000, ChinaDepartment of Stomatology, The Third Hospital of Shijiazhuang City, Shijiazhuang, Hebei, 050011, ChinaDepartment of Stomatology, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, ChinaDepartment of Medical Periodical Press, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei, 050017, ChinaOral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of interleukin-37 (IL-37) on oral cancer and its underlying mechanisms. Two oral cancer cell lines, HN13 and HSC-6, were employed in the study. Our findings reveal that IL-37 markedly inhibits cell viability and induces apoptosis in oral cancer cells. IL-37 attenuates the proliferation of oral cancer cells induced by lipopolysaccharide and tumor necrosis factor-alpha, while knockdown of IL-37 exacerbates this induction. Furthermore, IL-37 demonstrates anti-inflammatory effects on oral cancer cells. The modulation of inflammation, proliferation, apoptosis, and migration by IL-37 is mediated through the STAT3 pathway. The outcomes of this study contribute valuable insights to a deeper understanding of oral cancer pathogenesis and pave the way for the development of novel drugs for the treatment of this disease.https://doi.org/10.1515/med-2025-1173il-37oral cancercell growthstat3 |
| spellingShingle | Fang Jing Li Kunshan Zhang Liyuan Zhang Ying Wang Yifan Zhang Jing Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3 Open Medicine il-37 oral cancer cell growth stat3 |
| title | Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3 |
| title_full | Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3 |
| title_fullStr | Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3 |
| title_full_unstemmed | Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3 |
| title_short | Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3 |
| title_sort | interleukin 37 mediates the anti oral tumor activity in oral cancer through stat3 |
| topic | il-37 oral cancer cell growth stat3 |
| url | https://doi.org/10.1515/med-2025-1173 |
| work_keys_str_mv | AT fangjing interleukin37mediatestheantioraltumoractivityinoralcancerthroughstat3 AT likunshan interleukin37mediatestheantioraltumoractivityinoralcancerthroughstat3 AT zhangliyuan interleukin37mediatestheantioraltumoractivityinoralcancerthroughstat3 AT zhangying interleukin37mediatestheantioraltumoractivityinoralcancerthroughstat3 AT wangyifan interleukin37mediatestheantioraltumoractivityinoralcancerthroughstat3 AT zhangjing interleukin37mediatestheantioraltumoractivityinoralcancerthroughstat3 |