Andrographolide promotes the ex vivo expansion of CD34+ hematopoietic stem cells derived from human umbilical cord blood

Andrographolide promotes the ex vivo expansion of CD34+ hematopoietic stem cells derived from human umbilical cord blood

Abstract Umbilical cord blood (UCB) units are an alternative source of human hematopoietic stem cells (HSCs) for allogeneic stem cell transplants. A large quantity of HSCs is needed but the low number of accessible cells from UCB has been a significant limitation. Improving the ex vivo growth of HSC...

Full description

Saved in:

Bibliographic Details
Main Authors:	Nareerat Sutjarit, Laongthip Ruknarong, Chamnan Tanprasertkul, Kanit Bhukhai, Hay Man Saung Hnin Soe, Pakpoom Kheolamai, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Series:	Scientific Reports
Subjects:	Andrographolide Hematopoietic stem cells (HSCs) Ex vivo expansion Umbilical cord blood (UCB) Hematologic disorders Hematopoietic stem cell transplantation
Online Access:	https://doi.org/10.1038/s41598-025-15647-9
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Phenotypical changes of hematopoietic stem and progenitor cells in COVID-19 patients: Correlation with disease status
by: Hosni A. M. Hussein, et al.
Published: (2023-07-01)

High glucose inhibits proliferation, migration, and osteogenic differentiation of human placenta-derived mesenchymal stem cells
by: Supawadee Duangprom, et al.
Published: (2025-07-01)

Human Mesenchymal Stem Cells Derived from the Placenta and Chorion Suppress the Proliferation while Enhancing the Migration of Human Breast Cancer Cells
by: Sarawut Sirithammajak, et al.
Published: (2022-01-01)

Improvement of osteogenic differentiation in umbilical cord-derived human mesenchymal stem cells through specific MiRNA inhibition
by: Ladda Meesuk, et al.
Published: (2025-08-01)

The Effects of High Glucose on Adipogenic and Osteogenic Differentiation of Gestational Tissue-Derived MSCs
by: Weerawan Hankamolsiri, et al.
Published: (2016-01-01)

Editorial: Hematopoietic stress in stem cell homeostasis and disease pathogenesis
by: Jing Ma, et al.
Published: (2025-03-01)

Factors associated with the number of CD34-positive hematopoietic progenitor cells in the leukocyte concentrate in patients with lymphomas and acute T-lymphoblastic leukemia
by: I. V. Galtseva, et al.
Published: (2024-12-01)

Equivalents of the neutrophil-to-lymphocyte ratio of circulating pool of stem and immature hematopoietic cells for assessing liver transplant status
by: A. N. Shutko, et al.
Published: (2023-09-01)

Exploring hematopoietic stem cell awareness and engagement among healthcare professionals: A cross-sectional survey
by: Vikash Chandra Mishra, et al.
Published: (2024-12-01)

Stem cell therapy: a revolutionary cure or a pandora's box
by: Hany E. Marei
Published: (2025-05-01)

Gestational Tissue-Derived Human Mesenchymal Stem Cells Use Distinct Combinations of Bioactive Molecules to Suppress the Proliferation of Human Hepatoblastoma and Colorectal Cancer Cells
by: Nitchapon Paiboon, et al.
Published: (2019-01-01)

Repurposing of an inotropic drug dobutamine to enhance the production of human hematopoietic stem cells from human induced pluripotent stem cells
by: Chuti Laowtammathron, et al.
Published: (2025-06-01)

Autologous hematopoietic stem cell transplantation in the treatment of systemic sclerosis. Part 1. Clinical aspects
by: O. B. Ovsyannikova, et al.
Published: (2020-11-01)

Editorial: Advancements in hematopoietic stem cell proliferation and self-renewal maintenance
by: Pawan Kumar Raghav, et al.
Published: (2025-07-01)

Benefits of serum protein electrophoresis as part of hematopoietic stem cell donor clearance
by: Laura Kilinc, et al.
Published: (2024-10-01)

Hematopoietic stem cell discovery: unveiling the historical and future perspective of colony-forming units assay
by: Nur Afizah Yusoff, et al.
Published: (2025-01-01)

The impact of multiple myeloma drugs treatments on autologous stem cell transplantation in the era of new drugs
by: Xixi Wan, et al.
Published: (2025-02-01)

Results of allogeneic hematopoietic stem cell transplantation in a patient with classical Hodgkin's lymphoma
by: A. Р. Strelnikova, et al.
Published: (2021-05-01)

Long-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two cases
by: Jing-wen Niu, et al.
Published: (2025-02-01)

Role of Defects of Hematopoietic and Lymphoid Niches in Genesis of Chronic Lymphocytic Leukemia
by: NYu Semenova, et al.
Published: (2016-04-01)

RELATIONSHIP BETWEEN CD34/CD45 POSITIVE CELLS CONCENTRATION IN BLOOD OF HEART RECIPIENTS AND LEVEL OF GRAFT VASCULOPATHY RISK BIOMARKERS
by: O. P. Shevchenko, et al.
Published: (2013-05-01)

EVALUATION OF QUALITATIVE AND QUANTITATIVE INDICATORS OF SUBSTITUTIONARY TRANSFUSION THERAPY IN DIFFERENT TYPES OF HEMATOPOIETIC STEM CELL TRANSPLANTATION
by: M. A. Kucher, et al.
Published: (2017-03-01)

Features of transfusion therapy in hematopoietic stem cell transplantation
by: M. A. Kucher, et al.
Published: (2016-12-01)

Dynamic Changes of Immunoreactive CD34, CD117, and CD41 Hematopoietic Stem Cells in Human Placentas of Different Gestational Ages
by: Sanja Jovicic, et al.
Published: (2025-05-01)

CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION
by: Rafael de la Camara
Published: (2016-06-01)

Infectious Causes of Early Mortality After Hematopoietic Stem Cell Transplantation
by: Pelin İrkören, et al.
Published: (2024-12-01)

Modified screening and management strategies for chronic rhinosinusitis in hematologic patients receiving hematopoietic stem cell transplantation
by: Yen-Hui Lee, et al.
Published: (2025-02-01)

PARASITIC INFECTIONS IN HEMATOPOIETIC STEM CELL TRANSPLANTATION
by: Isidro Jarque, et al.
Published: (2016-07-01)

LYMPHOID NEOPLASMS AFTER ALLOGENEIC HEMATOPOIETIC STEM CELLS TRANSPLANTATION. THE CASE OF SECONDARY HODGKIN’S LYMPHOMA, DIFFERENTIAL DIAGNOSIS WITH POST-TRANSPLANT LYMPHOPROLIFERATIVE DISEASE
by: Yu. V. Skvortsova, et al.
Published: (2017-06-01)

Late non-infectious lung damage in children after allogeneic hematopoietic stem cells transplantation
by: Yu. V. Skvortsova, et al.
Published: (2015-06-01)

Therapy efficacy in multiple myeloma patients received autologous stem cells transplantation as first line therapy
by: Ye. I. Darskaya, et al.
Published: (2014-07-01)

Intercellular network structure and regulatory motifs in the human hematopoietic system
by: Wenlian Qiao, et al.
Published: (2014-07-01)

CLINICAL EFFECTIVENESS OF HIGH-DOSE IMMUNOSUPPRESSIVE THERAPY WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN MULTIPLE SCLEROSIS PATIENTS
by: D. A. Fedorenko, et al.
Published: (2014-12-01)

Nosocomial pneumonia caused by water-born Legionella pneumophila in a pediatric hematopoietic stem cell transplantation recipient for thalassemia major
by: Tuğba Erat, et al.
Published: (2020-10-01)

АВ0-INCOMPATIBILITY IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION: 15-YEARS EXPERIENCE OF R.M. GORBACHEVA MEMORIAL RESEARCH INSTITUTE FOR CHILDREN ONCOLOGY, HEMATOLOGY AND TRANSPLANTATION
by: M. A. Kucher, et al.
Published: (2017-01-01)

Cryostorage of peripheral blood hematopoietic stem cells in transplantology: current status and prospects
by: O. I. Kit, et al.
Published: (2023-12-01)

POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS: ROLE OF VIRAL INFECTION, GENETIC LESIONS AND ANTIGEN STIMULATION IN THE PATHOGENESIS OF THE DISEASE
by: Daniela Capello, et al.
Published: (2009-11-01)

Seasonal Characterization of the Aerobiome in Hematopoietic Stem Cell Transplant Rooms: Potential Risk for Immunosuppressed Patients
by: Emilio Mariano Durán-Manuel, et al.
Published: (2024-11-01)

Guest Editor: Raffaella Origa IRON TOXICITY AND HEMOPOIETIC CELL TRANSPLANTATION: TIME TO CHANGE THE PARADIGM.
by: Federica Pilo
Published: (2019-04-01)

Successful dupilumab treatment in a patient with severe dermatitis following allogenic hematopoietic stem cell transplantation
by: Young-Hee Nam, et al.
Published: (2025-04-01)