Association between Alpha- Klotho Protein, Calcium, and Phosphate concentrations in Adult Iraqi Patients with Beta-Thalassemia Major
Background: Beta-thalassemia major is a prevalent global condition characterized by a rapid breakdown of red blood cells. Regular blood transfusions can give rise to problems such as cardiovascular disease, diabetes, osteoporosis, and renal disorders. Alpha-Klotho protein is a protein that has anti...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2024-12-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2391 |
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| Summary: | Background: Beta-thalassemia major is a prevalent global condition characterized by a rapid breakdown of red blood cells. Regular blood transfusions can give rise to problems such as cardiovascular disease, diabetes, osteoporosis, and renal disorders. Alpha-Klotho protein is a protein that has anti-aging properties and is involved in several functions, including reducing oxidative stress, regulating energy metabolism through several routes, and managing calcium and phosphate metabolism.
Objective: This study aimed to assess changes in calcium and phosphate levels, Alpha-Klotho protein concentration, and their associations with cardiac dysfunction in patients with Beta-thalassemia major.
Methods: The study was conducted at Al-Sadr General Hospital and Ibn Albaladi Center of Blood Diseases, Baghdad, and involved 90 participants who were grouped into three groups: Group A: 30 patients with Beta-thalassemia major and heart dysfunction; Group B:30 patients with Beta-thalassemia major without any signs of heart dysfunction; and Group C:30 healthy individuals as a control group. The indicators examined were serum levels of Alpha-klotho protein, calcium, phosphate, and Ferritin. ELISA method was used to assess serum Alpha-klotho protein, whereas serum Ca, serum phosphate, and serum Ferritin were analyzed using the Beckman Coulter AU clinical chemistry analyzers.
Results: The mean values of Serum Alpha-Klotho protein, phosphate, and Ferritin in the patients with beta-thalassemia were greater than those in the control group with P value<0.05. Patients with thalassemia had decreased levels of serum calcium compared to the control group. Additionally, a strong negative association was observed between serum calcium and phosphate levels.
Conclusion: Patients with beta-thalassemia major have significant alterations in calcium and phosphate levels under the control of Klotho protein levels.
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| ISSN: | 0041-9419 2410-8057 |