An intricate role of Ang II/AT1 in the modulation of monosodium glutamate-induced pulmonary fibrosis by TGF-β/Smad through quercetin

An intricate role of Ang II/AT1 in the modulation of monosodium glutamate-induced pulmonary fibrosis by TGF-β/Smad through quercetin

Abstract To investigate the protective actions of the natural flavonoid quercetin against monosodium glutamate (MSG)-induced pulmonary fibrosis in rats, the present study targets the modulation of the TGF-β/Smad signaling pathway and the involvement of Ang II/AT1. The experimental model involved the...

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Bibliographic Details
Main Authors: Arnab Banerjee, Debasmita Das, Krishnendu Manna, Jayati Roy, Sandip Mukherjee, Bithin Kumar Maji
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Quercetin
Monosodium glutamate
Pulmonary fibrosis
Pro-fibrotic cytokines
Oxidative stress
TGF-β/Smad
Online Access:https://doi.org/10.1038/s41598-025-05781-9
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https://doi.org/10.1038/s41598-025-05781-9

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