First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population
Objective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions. Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent rou...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2014/435037 |
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| author | Cláudia Teixeira Eduardo Tejera Helena Martins António Tomé Pereira Altamiro Costa-Pereira Irene Rebelo |
| author_facet | Cláudia Teixeira Eduardo Tejera Helena Martins António Tomé Pereira Altamiro Costa-Pereira Irene Rebelo |
| author_sort | Cláudia Teixeira |
| collection | DOAJ |
| description | Objective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions. Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent routine first trimester aneuploidy screening in a Portuguese university hospital from January 2009 to June 2013. Logistic regression-based predictive models were developed for prediction of PE based on maternal characteristics, crown-rump length (CRL), nuchal translucency thickness (NT), and maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (free β-hCG). Results. At a false-positive rate of 5/10%, the detection rate for early-onset (EO-PE) and late-onset (LO-PE) PE was 31.4/45.7% and 29.5/35.2%, respectively. Although both forms of PE were associated with decreased PAPP-A, logistic regression analysis revealed significant contributions from maternal factors, free β-hCG, CRL, and NT, but not PAPP-A, for prediction of PE. Conclusion. Our findings support that both clinical forms of EO-PE and LO-PE can be predicted using a combination of maternal history and biomarkers assessed at first trimester aneuploidy screening. However, detection rates were modest, suggesting that models need to be improved with additional markers not included in the current aneuploidy screening programs. |
| format | Article |
| id | doaj-art-db07e78eb7a44428903d0e2686d0f637 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-db07e78eb7a44428903d0e2686d0f6372025-02-03T06:42:08ZengWileyObstetrics and Gynecology International1687-95891687-95972014-01-01201410.1155/2014/435037435037First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric PopulationCláudia Teixeira0Eduardo Tejera1Helena Martins2António Tomé Pereira3Altamiro Costa-Pereira4Irene Rebelo5Department of Pathology, Porto Hospital Center, 4099-001 Porto, PortugalInstitute for Molecular and Cell Biology (IBMC), University of Porto, 4150-180 Porto, PortugalDepartment of Pathology, Porto Hospital Center, 4099-001 Porto, PortugalDepartment of Women, Porto Hospital Center, 4099-001 Porto, PortugalDepartment of Health Information and Decision Sciences (CIDES), Faculty of Medicine, University of Porto, 4200-450 Porto, PortugalInstitute for Molecular and Cell Biology (IBMC), University of Porto, 4150-180 Porto, PortugalObjective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions. Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent routine first trimester aneuploidy screening in a Portuguese university hospital from January 2009 to June 2013. Logistic regression-based predictive models were developed for prediction of PE based on maternal characteristics, crown-rump length (CRL), nuchal translucency thickness (NT), and maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (free β-hCG). Results. At a false-positive rate of 5/10%, the detection rate for early-onset (EO-PE) and late-onset (LO-PE) PE was 31.4/45.7% and 29.5/35.2%, respectively. Although both forms of PE were associated with decreased PAPP-A, logistic regression analysis revealed significant contributions from maternal factors, free β-hCG, CRL, and NT, but not PAPP-A, for prediction of PE. Conclusion. Our findings support that both clinical forms of EO-PE and LO-PE can be predicted using a combination of maternal history and biomarkers assessed at first trimester aneuploidy screening. However, detection rates were modest, suggesting that models need to be improved with additional markers not included in the current aneuploidy screening programs.http://dx.doi.org/10.1155/2014/435037 |
| spellingShingle | Cláudia Teixeira Eduardo Tejera Helena Martins António Tomé Pereira Altamiro Costa-Pereira Irene Rebelo First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population Obstetrics and Gynecology International |
| title | First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population |
| title_full | First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population |
| title_fullStr | First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population |
| title_full_unstemmed | First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population |
| title_short | First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population |
| title_sort | first trimester aneuploidy screening program for preeclampsia prediction in a portuguese obstetric population |
| url | http://dx.doi.org/10.1155/2014/435037 |
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