Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia
Objective. To investigate efficiency of RAGE and OSM as new prognosis biomarkers of severe pneumonia. Methods. Eligible patients were classified into hypoxemia and nonhypoxemia groups. Meanwhile, the same cohort was divided into survival and nonsurvival groups after a post-hospital stay of 30 days....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2022/3854191 |
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| _version_ | 1832561323047649280 |
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| author | Jing Lei Li Wang Qian Li Lin Gao Jing Zhang Yan Tan |
| author_facet | Jing Lei Li Wang Qian Li Lin Gao Jing Zhang Yan Tan |
| author_sort | Jing Lei |
| collection | DOAJ |
| description | Objective. To investigate efficiency of RAGE and OSM as new prognosis biomarkers of severe pneumonia. Methods. Eligible patients were classified into hypoxemia and nonhypoxemia groups. Meanwhile, the same cohort was divided into survival and nonsurvival groups after a post-hospital stay of 30 days. We analyzed risk factors for the hypoxia and death among these patients. Results. Compared with nonsurvival group, significant increase was noticed in PH, lymphocyte, albumin and platelet level in survival group, while significant decline was noticed in neutrophils, RBC, hemoglobin, hematocrit, creatinine, total bilirubin, CRP, PCT, OSM, RAGE and neutrophils/lymphocyte level. Oxygenation index level was related to APACHE II, LIS, SOFA, NUTRIC score, WBC, neutrophils, lymphocyte, RAGE, and albumin level (p<0.05). LIS, SOFA, NUTRIC score, lac, lymphocyte, platelet, BUN, total bilirubin, PCT, and OSM levels were associated with mortality rate (p<0.05). Conclusions. RAGE and OSM may serve as a new biomarker for poor prognosis in pneumonia patients. |
| format | Article |
| id | doaj-art-daef4f3c0afb435080cc200c19028c08 |
| institution | Kabale University |
| issn | 1916-7245 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-daef4f3c0afb435080cc200c19028c082025-02-03T01:25:21ZengWileyCanadian Respiratory Journal1916-72452022-01-01202210.1155/2022/3854191Identification of RAGE and OSM as New Prognosis Biomarkers of Severe PneumoniaJing Lei0Li Wang1Qian Li2Lin Gao3Jing Zhang4Yan Tan5Department of Respiratory and Critical MedicineDepartment of Respiratory and Critical MedicineDepartment of Respiratory and Critical MedicineDepartment of Respiratory and Critical MedicineDepartment of Respiratory and Critical MedicineDepartment of Respiratory and Critical MedicineObjective. To investigate efficiency of RAGE and OSM as new prognosis biomarkers of severe pneumonia. Methods. Eligible patients were classified into hypoxemia and nonhypoxemia groups. Meanwhile, the same cohort was divided into survival and nonsurvival groups after a post-hospital stay of 30 days. We analyzed risk factors for the hypoxia and death among these patients. Results. Compared with nonsurvival group, significant increase was noticed in PH, lymphocyte, albumin and platelet level in survival group, while significant decline was noticed in neutrophils, RBC, hemoglobin, hematocrit, creatinine, total bilirubin, CRP, PCT, OSM, RAGE and neutrophils/lymphocyte level. Oxygenation index level was related to APACHE II, LIS, SOFA, NUTRIC score, WBC, neutrophils, lymphocyte, RAGE, and albumin level (p<0.05). LIS, SOFA, NUTRIC score, lac, lymphocyte, platelet, BUN, total bilirubin, PCT, and OSM levels were associated with mortality rate (p<0.05). Conclusions. RAGE and OSM may serve as a new biomarker for poor prognosis in pneumonia patients.http://dx.doi.org/10.1155/2022/3854191 |
| spellingShingle | Jing Lei Li Wang Qian Li Lin Gao Jing Zhang Yan Tan Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia Canadian Respiratory Journal |
| title | Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia |
| title_full | Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia |
| title_fullStr | Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia |
| title_full_unstemmed | Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia |
| title_short | Identification of RAGE and OSM as New Prognosis Biomarkers of Severe Pneumonia |
| title_sort | identification of rage and osm as new prognosis biomarkers of severe pneumonia |
| url | http://dx.doi.org/10.1155/2022/3854191 |
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