Trichosanthes kirilowii Maxim. Polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota
Polysaccharide, a chain of sugars bound by glycosidic bonds, have a wide range of physiological activities, including hypoglycemic activity. In present study, we established T2DM mice models to explore the effects and mechanism of Trichosanthes kirilowii Maxim polysaccharide (TMSP1) on high-fat diet...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Current Research in Food Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927125000085 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590919526776832 |
|---|---|
| author | Qiaoying Song Kunpeng Zhang Shuyan Li Shaoting Weng |
| author_facet | Qiaoying Song Kunpeng Zhang Shuyan Li Shaoting Weng |
| author_sort | Qiaoying Song |
| collection | DOAJ |
| description | Polysaccharide, a chain of sugars bound by glycosidic bonds, have a wide range of physiological activities, including hypoglycemic activity. In present study, we established T2DM mice models to explore the effects and mechanism of Trichosanthes kirilowii Maxim polysaccharide (TMSP1) on high-fat diet/streptozotocin (HF-STZ) induced diabetes mice. The results showed that high-fat diet significantly increased the oral glucose tolerance test (OGTT), viscera index, oxidative stress, impaired glucose tolerance, decreased body weight, immune response and short-chain fatty acid (SCFAs) content, and disrupted the balance of intestinal flora structure. However, after 6 weeks of TMSP1 intervention decreased lipid accumulation, ameliorated gut microbiota dysbiosis by increasing SCFAs-producing bacteria and mitigated intestinal inflammation and oxidative stress. Moreover, TMSP1 significantly restored the integrity of the intestinal epithelial barrier and mucus barrier. The results of fecal microbiota transplantation confirmed that TMSP1 exerted hypoglycemic effect through regulating intestinal flora to a certain extent. Collectively, the findings revealed TMSP1 intervention inhibits hyperglycemia by improving gut microbiota disorder, lipid metabolism, and inflammation. Hence, TMSP1 may be an effective measure to ameliorate HF-STZ induced diabetes. |
| format | Article |
| id | doaj-art-dae5856f9c034704a0f6d664ecef0865 |
| institution | Kabale University |
| issn | 2665-9271 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj-art-dae5856f9c034704a0f6d664ecef08652025-01-23T05:27:43ZengElsevierCurrent Research in Food Science2665-92712025-01-0110100977Trichosanthes kirilowii Maxim. Polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiotaQiaoying Song0Kunpeng Zhang1Shuyan Li2Shaoting Weng3College of Biotechnology and Food Science, Anyang Institute of Technology, Huanghe Road, Anyang, 455000, ChinaCorresponding author.; College of Biotechnology and Food Science, Anyang Institute of Technology, Huanghe Road, Anyang, 455000, ChinaCollege of Biotechnology and Food Science, Anyang Institute of Technology, Huanghe Road, Anyang, 455000, ChinaCollege of Biotechnology and Food Science, Anyang Institute of Technology, Huanghe Road, Anyang, 455000, ChinaPolysaccharide, a chain of sugars bound by glycosidic bonds, have a wide range of physiological activities, including hypoglycemic activity. In present study, we established T2DM mice models to explore the effects and mechanism of Trichosanthes kirilowii Maxim polysaccharide (TMSP1) on high-fat diet/streptozotocin (HF-STZ) induced diabetes mice. The results showed that high-fat diet significantly increased the oral glucose tolerance test (OGTT), viscera index, oxidative stress, impaired glucose tolerance, decreased body weight, immune response and short-chain fatty acid (SCFAs) content, and disrupted the balance of intestinal flora structure. However, after 6 weeks of TMSP1 intervention decreased lipid accumulation, ameliorated gut microbiota dysbiosis by increasing SCFAs-producing bacteria and mitigated intestinal inflammation and oxidative stress. Moreover, TMSP1 significantly restored the integrity of the intestinal epithelial barrier and mucus barrier. The results of fecal microbiota transplantation confirmed that TMSP1 exerted hypoglycemic effect through regulating intestinal flora to a certain extent. Collectively, the findings revealed TMSP1 intervention inhibits hyperglycemia by improving gut microbiota disorder, lipid metabolism, and inflammation. Hence, TMSP1 may be an effective measure to ameliorate HF-STZ induced diabetes.http://www.sciencedirect.com/science/article/pii/S2665927125000085Trichosanthes kirilowii maxim.PolysaccharideT2DM |
| spellingShingle | Qiaoying Song Kunpeng Zhang Shuyan Li Shaoting Weng Trichosanthes kirilowii Maxim. Polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota Current Research in Food Science Trichosanthes kirilowii maxim. Polysaccharide T2DM |
| title | Trichosanthes kirilowii Maxim. Polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota |
| title_full | Trichosanthes kirilowii Maxim. Polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota |
| title_fullStr | Trichosanthes kirilowii Maxim. Polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota |
| title_full_unstemmed | Trichosanthes kirilowii Maxim. Polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota |
| title_short | Trichosanthes kirilowii Maxim. Polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota |
| title_sort | trichosanthes kirilowii maxim polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota |
| topic | Trichosanthes kirilowii maxim. Polysaccharide T2DM |
| url | http://www.sciencedirect.com/science/article/pii/S2665927125000085 |
| work_keys_str_mv | AT qiaoyingsong trichosantheskirilowiimaximpolysaccharideattenuatesdiabetesthroughthesynergisticimpactoflipidmetabolismandmodulatinggutmicrobiota AT kunpengzhang trichosantheskirilowiimaximpolysaccharideattenuatesdiabetesthroughthesynergisticimpactoflipidmetabolismandmodulatinggutmicrobiota AT shuyanli trichosantheskirilowiimaximpolysaccharideattenuatesdiabetesthroughthesynergisticimpactoflipidmetabolismandmodulatinggutmicrobiota AT shaotingweng trichosantheskirilowiimaximpolysaccharideattenuatesdiabetesthroughthesynergisticimpactoflipidmetabolismandmodulatinggutmicrobiota |