A three-dimensional mouse liver organoid platform for assessing EDCs metabolites simulating liver metabolism

A three-dimensional mouse liver organoid platform for assessing EDCs metabolites simulating liver metabolism

Hepatic metabolism is an important process for evaluate the potential activity and toxicity of endocrine disrupting chemicals (EDCs) metabolites. Organization for Economic Co-operation and Development (OECD) has advocated the development of in vitro assays that mimic in vivo hepatic metabolism to ev...

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Bibliographic Details
Main Authors: Ji Hyun Moon, Hyun-Soo Roh, Young Jae Park, Hyun Ho Song, Jieun Choi, Da Woon Jung, Soo Jin Park, Ho Jin Park, So-Hyeon Park, Da-Eun Kim, Gahee Kim, Joong-Hyuck Auh, Dong Ha Bhang, Hong Jin Lee, Do Yup Lee
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Environment International
Subjects:
Endocrine-disrupting chemicals
OECD test guideline
Liver metabolism
Mouse liver organoids
Bioactivation
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412024007700
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