An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant
A 60-year-old female who has a history significant for diabetes, depression, and rheumatoid arthritis presented with a progressively enlarging hematoma of the left upper extremity. She was found to have an enlarging hematoma and an isolated elevation of activated partial thromboplastin time (aPTT)....
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/521785 |
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| author | Srikanth Seethala Nathaniel P. Collins George Comerci |
| author_facet | Srikanth Seethala Nathaniel P. Collins George Comerci |
| author_sort | Srikanth Seethala |
| collection | DOAJ |
| description | A 60-year-old female who has a history significant for diabetes, depression, and rheumatoid arthritis presented with a progressively enlarging hematoma of the left upper extremity. She was found to have an enlarging hematoma and an isolated elevation of activated partial thromboplastin time (aPTT). Lab work-up revealed low factor VIII activity levels and inhibitor titers at 13.38 Bethesda units (BU). Dilute Russell’s viper venom time (dRVVT) revealed a lupus anticoagulant. Hemostasis was achieved with factor VIII inhibitor bypassing activity (FEIBA) and inhibitor eradication with-rituxan after the failure of first-line treatment with cyclophosphamide and prednisone. |
| format | Article |
| id | doaj-art-dad4d6af914c440fac6a13be0d984ade |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-dad4d6af914c440fac6a13be0d984ade2025-02-03T01:02:20ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/521785521785An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus AnticoagulantSrikanth Seethala0Nathaniel P. Collins1George Comerci2Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USADepartment of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USADepartment of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USAA 60-year-old female who has a history significant for diabetes, depression, and rheumatoid arthritis presented with a progressively enlarging hematoma of the left upper extremity. She was found to have an enlarging hematoma and an isolated elevation of activated partial thromboplastin time (aPTT). Lab work-up revealed low factor VIII activity levels and inhibitor titers at 13.38 Bethesda units (BU). Dilute Russell’s viper venom time (dRVVT) revealed a lupus anticoagulant. Hemostasis was achieved with factor VIII inhibitor bypassing activity (FEIBA) and inhibitor eradication with-rituxan after the failure of first-line treatment with cyclophosphamide and prednisone.http://dx.doi.org/10.1155/2013/521785 |
| spellingShingle | Srikanth Seethala Nathaniel P. Collins George Comerci An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant Case Reports in Hematology |
| title | An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant |
| title_full | An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant |
| title_fullStr | An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant |
| title_full_unstemmed | An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant |
| title_short | An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant |
| title_sort | unusual etiology for elevation of activated partial thromboplastin time aptt in sle acquired hemophilia and lupus anticoagulant |
| url | http://dx.doi.org/10.1155/2013/521785 |
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