CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type
Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted beca...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3730915 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556710834733056 |
|---|---|
| author | Alexandra Papoudou-Bai Leonidas Marinos Amalia Vassou Eleni Kapsali Panagiotis Kanavaros |
| author_facet | Alexandra Papoudou-Bai Leonidas Marinos Amalia Vassou Eleni Kapsali Panagiotis Kanavaros |
| author_sort | Alexandra Papoudou-Bai |
| collection | DOAJ |
| description | Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Histological examination of the skin biopsy disclosed a diffuse dermal infiltration by large lymphoid cells. Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. Thus, the diagnosis of a CD5+ PCDLBCL-LT was made. Despite treatment, the patient died 11 months after initial diagnosis. |
| format | Article |
| id | doaj-art-dacfe2183e224d65abf839204f5dc82d |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-dacfe2183e224d65abf839204f5dc82d2025-02-03T05:44:41ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712019-01-01201910.1155/2019/37309153730915CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg TypeAlexandra Papoudou-Bai0Leonidas Marinos1Amalia Vassou2Eleni Kapsali3Panagiotis Kanavaros4Department of Pathology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Hematopathology, Evangelismos General Hospital, Athens, GreeceDepartment of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceMost primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Histological examination of the skin biopsy disclosed a diffuse dermal infiltration by large lymphoid cells. Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. Thus, the diagnosis of a CD5+ PCDLBCL-LT was made. Despite treatment, the patient died 11 months after initial diagnosis.http://dx.doi.org/10.1155/2019/3730915 |
| spellingShingle | Alexandra Papoudou-Bai Leonidas Marinos Amalia Vassou Eleni Kapsali Panagiotis Kanavaros CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type Case Reports in Dermatological Medicine |
| title | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
| title_full | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
| title_fullStr | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
| title_full_unstemmed | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
| title_short | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
| title_sort | cd5 positive primary cutaneous diffuse large b cell lymphoma leg type |
| url | http://dx.doi.org/10.1155/2019/3730915 |
| work_keys_str_mv | AT alexandrapapoudoubai cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype AT leonidasmarinos cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype AT amaliavassou cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype AT elenikapsali cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype AT panagiotiskanavaros cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype |