The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity
Obesity is a worldwide health problem due to the imbalance of energy intake and energy expenditure. Irisin, a newly identified exercise-responsive myokine, which is produced by the proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has emerged as a promising therapeuti...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/6572342 |
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| _version_ | 1832555248626958336 |
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| author | Hui Li Fang Wang Mu Yang Jiao Sun Yi Zhao Dongqi Tang |
| author_facet | Hui Li Fang Wang Mu Yang Jiao Sun Yi Zhao Dongqi Tang |
| author_sort | Hui Li |
| collection | DOAJ |
| description | Obesity is a worldwide health problem due to the imbalance of energy intake and energy expenditure. Irisin, a newly identified exercise-responsive myokine, which is produced by the proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has emerged as a promising therapeutic strategy to combat obesity and obesity-related complications. Various studies in mice have shown that irisin could respond to systematic exercise training and promote white-to-brown fat transdifferentiation, but the role and function of irisin in humans are controversial. In this review, we systematically introduced and analyzed the factors that may contribute to these inconsistent results. Furthermore, we also described the potential anti-inflammatory properties of irisin under a variety of inflammatory conditions. Finally, the review discussed the existing unresolved issues and controversies about irisin, including the transcription of the irisin precursor FNDC5 gene in humans, the cleavage site of the yet unknown proteolytic enzyme that cleaves irisin from FNDC5, and the reliability of irisin levels measured with available detection methods. |
| format | Article |
| id | doaj-art-dac6a909de524853b894883173a5ea1f |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-dac6a909de524853b894883173a5ea1f2025-02-03T05:49:15ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/65723426572342The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for ObesityHui Li0Fang Wang1Mu Yang2Jiao Sun3Yi Zhao4Dongqi Tang5Center for Gene and Immunotherapy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, ChinaInstitute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, ChinaCenter for Gene and Immunotherapy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, ChinaCenter for Gene and Immunotherapy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, ChinaCenter for Gene and Immunotherapy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, ChinaCenter for Gene and Immunotherapy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, ChinaObesity is a worldwide health problem due to the imbalance of energy intake and energy expenditure. Irisin, a newly identified exercise-responsive myokine, which is produced by the proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has emerged as a promising therapeutic strategy to combat obesity and obesity-related complications. Various studies in mice have shown that irisin could respond to systematic exercise training and promote white-to-brown fat transdifferentiation, but the role and function of irisin in humans are controversial. In this review, we systematically introduced and analyzed the factors that may contribute to these inconsistent results. Furthermore, we also described the potential anti-inflammatory properties of irisin under a variety of inflammatory conditions. Finally, the review discussed the existing unresolved issues and controversies about irisin, including the transcription of the irisin precursor FNDC5 gene in humans, the cleavage site of the yet unknown proteolytic enzyme that cleaves irisin from FNDC5, and the reliability of irisin levels measured with available detection methods.http://dx.doi.org/10.1155/2021/6572342 |
| spellingShingle | Hui Li Fang Wang Mu Yang Jiao Sun Yi Zhao Dongqi Tang The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity International Journal of Endocrinology |
| title | The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity |
| title_full | The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity |
| title_fullStr | The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity |
| title_full_unstemmed | The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity |
| title_short | The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity |
| title_sort | effect of irisin as a metabolic regulator and its therapeutic potential for obesity |
| url | http://dx.doi.org/10.1155/2021/6572342 |
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