Downstream Signaling of Muscarinic M4 Receptors Is Regulated by Receptor Density and Cellular Environment

ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeut...

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Bibliographic Details
Main Authors: Madeleine Merz, Charlotte Playle, Monika Palchaudhuri, Oliver Hucke, Ulrike Gross, Daniel Ursu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Pharmacology Research & Perspectives
Online Access:https://doi.org/10.1002/prp2.70123
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