Estimated Pulse Wave Velocity Is Associated With All‐Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney Disease
ABSTRACT This study aimed to assess the correlation between estimated pulse wave velocity (ePWV) and mortality rates related to all‐cause and cardiovascular disease (CVD) among individuals diagnosed with chronic kidney disease (CKD) in the United States. A total of 4669 participants with CKD were id...
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14971 |
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| author | Xiao‐Hua Feng Yi Chen Xue‐Qi Chen Wei‐Hong Zhao |
| author_facet | Xiao‐Hua Feng Yi Chen Xue‐Qi Chen Wei‐Hong Zhao |
| author_sort | Xiao‐Hua Feng |
| collection | DOAJ |
| description | ABSTRACT This study aimed to assess the correlation between estimated pulse wave velocity (ePWV) and mortality rates related to all‐cause and cardiovascular disease (CVD) among individuals diagnosed with chronic kidney disease (CKD) in the United States. A total of 4669 participants with CKD were identified from the National Health and Nutrition Examination Survey conducted between 1999 and 2018. We calculated the incidence of CKD using an estimated glomerular filtration rate (eGFR) of < 60 mL/min/1.73 m2. Our study examined the association between ePWV and mortality risk based on weighted Kaplan–Meier plots and multivariate Cox regression. Linear testing between ePWV and mortality from all causes and CVD was performed using restricted cubic splines and Cox regression. This study included 4669 patients with CKD from the NHANES, representing 37 million Americans with CKD. There was a mean age of 71.9 years, and 48.1% of participants were male. With every increase of 1 m/s in ePWV measurement, there is a corresponding 31% (hazard ratio [HR]: 1.31, 95% confidence interval [CI]: 1.28–1.34) increase in the rate of mortality from all causes and a 32% (HR: 1.32, 95% CI: 1.27–1.37) increase in the rate of mortality from CVD. A significantly higher rate of cardiovascular and all‐cause mortality was observed in patients with CKD with elevated ePWV than in those with lower ePWV, as shown in the weighted Kaplan–Meier plots. Patients with CKD have a significant relationship between ePWV and all‐cause and cardiovascular mortality. |
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| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-dabea16f9bfd441db23ec0cb9a9981732025-01-31T05:38:37ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14971Estimated Pulse Wave Velocity Is Associated With All‐Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney DiseaseXiao‐Hua Feng0Yi Chen1Xue‐Qi Chen2Wei‐Hong Zhao3Division of Nephrology Department of Geriatrics Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital Nanjing P. R. ChinaDivision of Nephrology Department of Geriatrics Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital Nanjing P. R. ChinaDivision of Nephrology Department of Geriatrics Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital Nanjing P. R. ChinaDivision of Nephrology Department of Geriatrics Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital Nanjing P. R. ChinaABSTRACT This study aimed to assess the correlation between estimated pulse wave velocity (ePWV) and mortality rates related to all‐cause and cardiovascular disease (CVD) among individuals diagnosed with chronic kidney disease (CKD) in the United States. A total of 4669 participants with CKD were identified from the National Health and Nutrition Examination Survey conducted between 1999 and 2018. We calculated the incidence of CKD using an estimated glomerular filtration rate (eGFR) of < 60 mL/min/1.73 m2. Our study examined the association between ePWV and mortality risk based on weighted Kaplan–Meier plots and multivariate Cox regression. Linear testing between ePWV and mortality from all causes and CVD was performed using restricted cubic splines and Cox regression. This study included 4669 patients with CKD from the NHANES, representing 37 million Americans with CKD. There was a mean age of 71.9 years, and 48.1% of participants were male. With every increase of 1 m/s in ePWV measurement, there is a corresponding 31% (hazard ratio [HR]: 1.31, 95% confidence interval [CI]: 1.28–1.34) increase in the rate of mortality from all causes and a 32% (HR: 1.32, 95% CI: 1.27–1.37) increase in the rate of mortality from CVD. A significantly higher rate of cardiovascular and all‐cause mortality was observed in patients with CKD with elevated ePWV than in those with lower ePWV, as shown in the weighted Kaplan–Meier plots. Patients with CKD have a significant relationship between ePWV and all‐cause and cardiovascular mortality.https://doi.org/10.1111/jch.14971all‐cause mortalityarterial stiffnesscardiovascular mortalitychronic kidney diseaseestimated pulse wave velocityNHANES |
| spellingShingle | Xiao‐Hua Feng Yi Chen Xue‐Qi Chen Wei‐Hong Zhao Estimated Pulse Wave Velocity Is Associated With All‐Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney Disease The Journal of Clinical Hypertension all‐cause mortality arterial stiffness cardiovascular mortality chronic kidney disease estimated pulse wave velocity NHANES |
| title | Estimated Pulse Wave Velocity Is Associated With All‐Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney Disease |
| title_full | Estimated Pulse Wave Velocity Is Associated With All‐Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney Disease |
| title_fullStr | Estimated Pulse Wave Velocity Is Associated With All‐Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney Disease |
| title_full_unstemmed | Estimated Pulse Wave Velocity Is Associated With All‐Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney Disease |
| title_short | Estimated Pulse Wave Velocity Is Associated With All‐Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney Disease |
| title_sort | estimated pulse wave velocity is associated with all cause mortality and cardiovascular mortality among adults with chronic kidney disease |
| topic | all‐cause mortality arterial stiffness cardiovascular mortality chronic kidney disease estimated pulse wave velocity NHANES |
| url | https://doi.org/10.1111/jch.14971 |
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