Roles and functions of tumor-infiltrating lymphocytes and tertiary lymphoid structures in gastric cancer progression

Roles and functions of tumor-infiltrating lymphocytes and tertiary lymphoid structures in gastric cancer progression

Gastric cancer (GC), a leading cause of cancer mortality, exhibits profound molecular heterogeneity and immunosuppressive tumor microenvironment (TME) features that limit therapeutic efficacy. This review elucidates the dual roles of tertiary lymphoid structures (TLS) and tumor-infiltrating lymphocy...

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Bibliographic Details
Main Authors: Zhiyuan Yao, Gengchen Li, Di Pan, Zichen Pei, Yan Fang, Haonan Liu, Zhengxiang Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
gastric cancer
tertiary lymphoid structures
tumor-infiltrating lymphocytes
tumor microenvironment
immune checkpoint inhibitors
progression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595070/full
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