Comprehensive analysis of RFC4 as a potential biomarker for regulating the immune microenvironment and predicting immune therapy response in lung adenocarcinoma

Comprehensive analysis of RFC4 as a potential biomarker for regulating the immune microenvironment and predicting immune therapy response in lung adenocarcinoma

BackgroundReplication factor C subunit 4 (RFC4) is crucial for initiating DNA replication via DNA polymerase δ and ϵ and is overexpressed in various cancers. However, its relationship with the tumor immune microenvironment (TIME), and immunotherapy response in lung adenocarcinoma (LUAD) remains uncl...

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Bibliographic Details
Main Authors: Jianqing Zheng, Na Lin, Bifen Huang, Min Wu, Lihua Xiao, Bingwei Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
lung adenocarcinoma
replication factor C subunit 4 (RFC4)
immune regulatory factors
tumor immune microenvironment
immune therapy response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578243/full
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