Development of a permethylation-based detection method for oligo/polysialic acid structures via tandem MALDI-TOF mass spectrometry

Development of a permethylation-based detection method for oligo/polysialic acid structures via tandem MALDI-TOF mass spectrometry

Oligo/polysialic acid (oligo/polySia) refers to a class of linear polymers composed of Sias, found extensively at the non-reducing ends of glycans across various organisms, from bacteria to vertebrates. Different types of oligo/polySia have been characterized, varying in Sia composition, α-ketosidic...

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Bibliographic Details
Main Authors: Kai Suzuki, Di Wu, Ken Kitajima, Nao Yamakawa, Takayuki Omoto, Masaya Hane, Chihiro Sato
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:BBA Advances
Subjects:
Oligosialic acid
Polysialic acid
Permethylation
MALDI TOF/TOF
Mass spectrometry
Polysialoglycoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S2667160325000183
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