Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease
Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus (DM) and has become the main cause of end-stage renal disease worldwide. In recent years, with the increasing incidence of DM, the pathogenesis of DKD has received increasing attention. The pathogenesis of DKD is diverse an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2352629 |
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| author | Jiangyuan Jin Mianzhi Zhang |
| author_facet | Jiangyuan Jin Mianzhi Zhang |
| author_sort | Jiangyuan Jin |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus (DM) and has become the main cause of end-stage renal disease worldwide. In recent years, with the increasing incidence of DM, the pathogenesis of DKD has received increasing attention. The pathogenesis of DKD is diverse and complex. Extracellular vesicles (EVs) contain cell-derived membrane proteins, nucleic acids (such as DNA and RNA) and other important cellular components and are involved in intercellular information and substance transmission. In recent years, an increasing number of studies have confirmed that EVs play an important role in the development of DKD. The purpose of this paper is to explain the potential diagnostic value of EVs in DKD, analyze the mechanism by which EVs participate in intercellular communication, and explore whether EVs may become drug carriers for targeted therapy to provide a reference for promoting the implementation and application of exosome therapy strategies in clinical practice. |
| format | Article |
| id | doaj-art-da82964841e546688e9b9ac02906a4ff |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-da82964841e546688e9b9ac02906a4ff2025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2352629Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney diseaseJiangyuan Jin0Mianzhi Zhang1Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaTianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaDiabetic kidney disease (DKD) is a serious complication of diabetes mellitus (DM) and has become the main cause of end-stage renal disease worldwide. In recent years, with the increasing incidence of DM, the pathogenesis of DKD has received increasing attention. The pathogenesis of DKD is diverse and complex. Extracellular vesicles (EVs) contain cell-derived membrane proteins, nucleic acids (such as DNA and RNA) and other important cellular components and are involved in intercellular information and substance transmission. In recent years, an increasing number of studies have confirmed that EVs play an important role in the development of DKD. The purpose of this paper is to explain the potential diagnostic value of EVs in DKD, analyze the mechanism by which EVs participate in intercellular communication, and explore whether EVs may become drug carriers for targeted therapy to provide a reference for promoting the implementation and application of exosome therapy strategies in clinical practice.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2352629Extracellular vesiclesdiabetic kidney diseaseinflammatory reactionoxidative stressintercellular communicationrenal fibrosis |
| spellingShingle | Jiangyuan Jin Mianzhi Zhang Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease Renal Failure Extracellular vesicles diabetic kidney disease inflammatory reaction oxidative stress intercellular communication renal fibrosis |
| title | Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease |
| title_full | Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease |
| title_fullStr | Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease |
| title_full_unstemmed | Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease |
| title_short | Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease |
| title_sort | research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease |
| topic | Extracellular vesicles diabetic kidney disease inflammatory reaction oxidative stress intercellular communication renal fibrosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2352629 |
| work_keys_str_mv | AT jiangyuanjin researchprogressontheroleofextracellularvesiclesinthepathogenesisofdiabetickidneydisease AT mianzhizhang researchprogressontheroleofextracellularvesiclesinthepathogenesisofdiabetickidneydisease |