Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI Imaging
Waldenstrom’s macroglobulinaemia is the most commonly reported subtype of lymphoplasmacytic lymphoma (LPL); it is characterised by IgM secretion. Neurological complications are common usually as a result of hyperviscosity. In rare cases, cells can infiltrate the central nervous system; this is known...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/3931709 |
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| author | Daniel Halperin Simon Hallam Athar Haroon Tom Butler Samir Agrawal |
| author_facet | Daniel Halperin Simon Hallam Athar Haroon Tom Butler Samir Agrawal |
| author_sort | Daniel Halperin |
| collection | DOAJ |
| description | Waldenstrom’s macroglobulinaemia is the most commonly reported subtype of lymphoplasmacytic lymphoma (LPL); it is characterised by IgM secretion. Neurological complications are common usually as a result of hyperviscosity. In rare cases, cells can infiltrate the central nervous system; this is known as Bing-Neel syndrome. We report the case of a 57-year-old male with lymphoplasmacytic lymphoma of the IgG-subtype with neurological symptoms and the consequent finding of lymphoplasmacytoid cells in his cerebrospinal fluid as well as deposits on MRI and PET-CT imaging. This is the first report of Bing-Neel syndrome in IgG-subtype LPL. We discuss the biological and radiological markers of his disease, including PET imaging, which has been minimal in this area to date. |
| format | Article |
| id | doaj-art-da81453b2e084d97b0e13c31293ed0ac |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-da81453b2e084d97b0e13c31293ed0ac2025-02-03T01:21:37ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/39317093931709Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI ImagingDaniel Halperin0Simon Hallam1Athar Haroon2Tom Butler3Samir Agrawal4Whipps Cross Hospital, London E11 1NR, UKSt Bartholomew’s Hospital, London EC1A 7BE, UKSt Bartholomew’s Hospital, London EC1A 7BE, UKRoyal London Hospital, London E1 1BB, UKSt Bartholomew’s Hospital, London EC1A 7BE, UKWaldenstrom’s macroglobulinaemia is the most commonly reported subtype of lymphoplasmacytic lymphoma (LPL); it is characterised by IgM secretion. Neurological complications are common usually as a result of hyperviscosity. In rare cases, cells can infiltrate the central nervous system; this is known as Bing-Neel syndrome. We report the case of a 57-year-old male with lymphoplasmacytic lymphoma of the IgG-subtype with neurological symptoms and the consequent finding of lymphoplasmacytoid cells in his cerebrospinal fluid as well as deposits on MRI and PET-CT imaging. This is the first report of Bing-Neel syndrome in IgG-subtype LPL. We discuss the biological and radiological markers of his disease, including PET imaging, which has been minimal in this area to date.http://dx.doi.org/10.1155/2016/3931709 |
| spellingShingle | Daniel Halperin Simon Hallam Athar Haroon Tom Butler Samir Agrawal Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI Imaging Case Reports in Hematology |
| title | Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI Imaging |
| title_full | Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI Imaging |
| title_fullStr | Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI Imaging |
| title_full_unstemmed | Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI Imaging |
| title_short | Bing-Neel Syndrome Case Report: A Previously Undocumented IgG Variant with MRI, PET/CT, and PET/MRI Imaging |
| title_sort | bing neel syndrome case report a previously undocumented igg variant with mri pet ct and pet mri imaging |
| url | http://dx.doi.org/10.1155/2016/3931709 |
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