A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation
Abstract Implantable peripheral nerve electrodes are crucial for monitoring health and alleviating symptoms of chronic diseases. Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue‐like electrodes suffer from unmanageable...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202412361 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540921824018432 |
|---|---|
| author | Xueyang Ren Wenjie Tang Yuehui Yuan Shisheng Chen Fangzhou Lu Jinyang Mao Jidan Fan Xufeng Wei Ming Chu Benhui Hu |
| author_facet | Xueyang Ren Wenjie Tang Yuehui Yuan Shisheng Chen Fangzhou Lu Jinyang Mao Jidan Fan Xufeng Wei Ming Chu Benhui Hu |
| author_sort | Xueyang Ren |
| collection | DOAJ |
| description | Abstract Implantable peripheral nerve electrodes are crucial for monitoring health and alleviating symptoms of chronic diseases. Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue‐like electrodes suffer from unmanageable operating forces, leading to high risks of nerve injury and fragile electrode‐tissue interfaces. Here, a peripheral nerve electrode is developed that simultaneously fulfills the criteria of body temperature softening and tissue‐like modulus (less than 0.8 MPa at 37 °C) after implantation. The central core is altered from the tri‐arm crosslinker to the star‐branched monomer to kill two birds (close the translation temperature to 37 °C and decrease the modulus after implantation) with one stone. Furthermore, the decreased interfacial impedance (325.1 ± 46.9 Ω at 1 kHz) and increased charge storage capacity (111.2 ± 5.8 mC cm−2) are achieved by an in situ electrografted conductive polymer on the strain‐insensitive conductive network of Au nanotubes. The electrodes are readily wrapped around nerves and applied for long‐term stimulation in vivo with minimal inflammation. Neuromodulation experiments demonstrate their potential clinical utility, including vagus nerve stimulation in rats to suppress seizures and alleviation of cardiac remodeling in a canine model of myocardial infarction. |
| format | Article |
| id | doaj-art-da7c384afc5147678c63d9a9b593b019 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-da7c384afc5147678c63d9a9b593b0192025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202412361A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust NeuromodulationXueyang Ren0Wenjie Tang1Yuehui Yuan2Shisheng Chen3Fangzhou Lu4Jinyang Mao5Jidan Fan6Xufeng Wei7Ming Chu8Benhui Hu9School of Biomedical Engineering and Informatics Nanjing Medical University Nanjing 211166 ChinaSchool of Biomedical Engineering and Informatics Nanjing Medical University Nanjing 211166 ChinaSchool of Biomedical Engineering and Informatics Nanjing Medical University Nanjing 211166 ChinaSchool of Biomedical Engineering and Informatics Nanjing Medical University Nanjing 211166 ChinaDepartment of Endocrinology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 ChinaThe Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou School of Clinical Medicine Nanjing Medical University Taizhou 225300 ChinaThe Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou School of Clinical Medicine Nanjing Medical University Taizhou 225300 ChinaThe Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou School of Clinical Medicine Nanjing Medical University Taizhou 225300 ChinaThe Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou School of Clinical Medicine Nanjing Medical University Taizhou 225300 ChinaSchool of Biomedical Engineering and Informatics Nanjing Medical University Nanjing 211166 ChinaAbstract Implantable peripheral nerve electrodes are crucial for monitoring health and alleviating symptoms of chronic diseases. Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue‐like electrodes suffer from unmanageable operating forces, leading to high risks of nerve injury and fragile electrode‐tissue interfaces. Here, a peripheral nerve electrode is developed that simultaneously fulfills the criteria of body temperature softening and tissue‐like modulus (less than 0.8 MPa at 37 °C) after implantation. The central core is altered from the tri‐arm crosslinker to the star‐branched monomer to kill two birds (close the translation temperature to 37 °C and decrease the modulus after implantation) with one stone. Furthermore, the decreased interfacial impedance (325.1 ± 46.9 Ω at 1 kHz) and increased charge storage capacity (111.2 ± 5.8 mC cm−2) are achieved by an in situ electrografted conductive polymer on the strain‐insensitive conductive network of Au nanotubes. The electrodes are readily wrapped around nerves and applied for long‐term stimulation in vivo with minimal inflammation. Neuromodulation experiments demonstrate their potential clinical utility, including vagus nerve stimulation in rats to suppress seizures and alleviation of cardiac remodeling in a canine model of myocardial infarction.https://doi.org/10.1002/advs.202412361in situ softeningmyocardial remodelingneuromodulationperipheral nerve electrodes |
| spellingShingle | Xueyang Ren Wenjie Tang Yuehui Yuan Shisheng Chen Fangzhou Lu Jinyang Mao Jidan Fan Xufeng Wei Ming Chu Benhui Hu A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation Advanced Science in situ softening myocardial remodeling neuromodulation peripheral nerve electrodes |
| title | A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation |
| title_full | A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation |
| title_fullStr | A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation |
| title_full_unstemmed | A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation |
| title_short | A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation |
| title_sort | body temperature triggered in situ softening peripheral nerve electrode for chronic robust neuromodulation |
| topic | in situ softening myocardial remodeling neuromodulation peripheral nerve electrodes |
| url | https://doi.org/10.1002/advs.202412361 |
| work_keys_str_mv | AT xueyangren abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT wenjietang abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT yuehuiyuan abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT shishengchen abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT fangzhoulu abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT jinyangmao abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT jidanfan abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT xufengwei abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT mingchu abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT benhuihu abodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT xueyangren bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT wenjietang bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT yuehuiyuan bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT shishengchen bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT fangzhoulu bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT jinyangmao bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT jidanfan bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT xufengwei bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT mingchu bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation AT benhuihu bodytemperaturetriggeredinsitusofteningperipheralnerveelectrodeforchronicrobustneuromodulation |