Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome
Abstract Objective: To verify the prevalence and factors associated with Non-Alcoholic Fatty Liver Disease (NAFLD) among women with Polycystic Ovary Syndrome (PCOS). Methods: A cross-sectional study was conducted with 53 patients with PCOS. The diagnosis of PCOS followed the Rotterdam criteria. Th...
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-01-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| author | Maria Elisa Franciscatto Juliana Bosso Taniguchi Raquel Wohlenberg Isadora Luísa Riedi Karen Oppermann |
| author_facet | Maria Elisa Franciscatto Juliana Bosso Taniguchi Raquel Wohlenberg Isadora Luísa Riedi Karen Oppermann |
| author_sort | Maria Elisa Franciscatto |
| collection | DOAJ |
| description | Abstract Objective: To verify the prevalence and factors associated with Non-Alcoholic Fatty Liver Disease (NAFLD) among women with Polycystic Ovary Syndrome (PCOS). Methods: A cross-sectional study was conducted with 53 patients with PCOS. The diagnosis of PCOS followed the Rotterdam criteria. The diagnosis of NAFLD was made through US showing hepatic steatosis, excluding significant alcohol consumption and chronic liver disease. The following variables were compared between the groups of women with and without NAFLD: age, race, anthropometric data, blood pressure levels, liver enzymes, glycemic and lipid profiles, total testosterone, presence of hirsutism, and metabolic syndrome (MS). Variables were compared between the groups using T-test, Mann-Whitney, and Chi-square tests. Results: Among 53 patients with PCOS, 50.9% had NAFLD. The NAFLD group had higher weight (p=0.003), BMI (p=0.001), waist circumference (p≤0.001), fasting glucose (p=0.021), HbA1C% (p=0.028), triglycerides (p=0.023), AST (p=0.004), ALT (p=0.001), higher prevalence of MS (p=0.004), and lower levels of HDL cholesterol (p=0.043). The other variables did not differ between the groups. Both groups were predominantly of caucasian race, and there was no significant difference in age. Conclusion: The prevalence of NAFLD among patients with PCOS was 50.9%. Metabolic and hepatic enzyme abnormalities were more prevalent in this group compared to the group without the disease. Obesity tripled the prevalence of NAFLD. |
| format | Article |
| id | doaj-art-da77c4f8834b49989040d456c19558a8 |
| institution | Kabale University |
| issn | 0100-7203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj-art-da77c4f8834b49989040d456c19558a82025-01-21T07:36:14ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032025-01-014610.61622/rbgo/2024rbgo81Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndromeMaria Elisa Franciscattohttps://orcid.org/0009-0009-1277-1201Juliana Bosso Taniguchihttps://orcid.org/0000-0002-0470-1096Raquel Wohlenberghttps://orcid.org/0000-0002-1458-3716Isadora Luísa Riedihttps://orcid.org/0009-0008-1163-8559Karen Oppermannhttps://orcid.org/0000-0002-5711-4653Abstract Objective: To verify the prevalence and factors associated with Non-Alcoholic Fatty Liver Disease (NAFLD) among women with Polycystic Ovary Syndrome (PCOS). Methods: A cross-sectional study was conducted with 53 patients with PCOS. The diagnosis of PCOS followed the Rotterdam criteria. The diagnosis of NAFLD was made through US showing hepatic steatosis, excluding significant alcohol consumption and chronic liver disease. The following variables were compared between the groups of women with and without NAFLD: age, race, anthropometric data, blood pressure levels, liver enzymes, glycemic and lipid profiles, total testosterone, presence of hirsutism, and metabolic syndrome (MS). Variables were compared between the groups using T-test, Mann-Whitney, and Chi-square tests. Results: Among 53 patients with PCOS, 50.9% had NAFLD. The NAFLD group had higher weight (p=0.003), BMI (p=0.001), waist circumference (p≤0.001), fasting glucose (p=0.021), HbA1C% (p=0.028), triglycerides (p=0.023), AST (p=0.004), ALT (p=0.001), higher prevalence of MS (p=0.004), and lower levels of HDL cholesterol (p=0.043). The other variables did not differ between the groups. Both groups were predominantly of caucasian race, and there was no significant difference in age. Conclusion: The prevalence of NAFLD among patients with PCOS was 50.9%. Metabolic and hepatic enzyme abnormalities were more prevalent in this group compared to the group without the disease. Obesity tripled the prevalence of NAFLD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100260&lng=en&tlng=enNon-alcoholic fatty liver diseasePolycystic ovary syndromeMetabolic syndromeAlcohol drinkingObesityWaist circumferenceHyperandrogenism |
| spellingShingle | Maria Elisa Franciscatto Juliana Bosso Taniguchi Raquel Wohlenberg Isadora Luísa Riedi Karen Oppermann Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome Revista Brasileira de Ginecologia e Obstetrícia Non-alcoholic fatty liver disease Polycystic ovary syndrome Metabolic syndrome Alcohol drinking Obesity Waist circumference Hyperandrogenism |
| title | Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome |
| title_full | Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome |
| title_fullStr | Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome |
| title_full_unstemmed | Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome |
| title_short | Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome |
| title_sort | prevalence and factors associated with non alcoholic fatty liver disease among women with polycystic ovary syndrome |
| topic | Non-alcoholic fatty liver disease Polycystic ovary syndrome Metabolic syndrome Alcohol drinking Obesity Waist circumference Hyperandrogenism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100260&lng=en&tlng=en |
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