Lessons from Cancer Immunoediting in Cutaneous Melanoma
We will revisit the dual role of the immune system in controlling and enabling tumor progression, known as cancer immunoediting. We will go through the different phases of this phenomenon, exposing the most relevant evidences obtained from experimental models and human clinical data, with special fo...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/192719 |
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| _version_ | 1832565064375205888 |
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| author | Mariana Aris María Marcela Barrio José Mordoh |
| author_facet | Mariana Aris María Marcela Barrio José Mordoh |
| author_sort | Mariana Aris |
| collection | DOAJ |
| description | We will revisit the dual role of the immune system in controlling and enabling tumor progression, known as cancer immunoediting. We will go through the different phases of this phenomenon, exposing the most relevant evidences obtained from experimental models and human clinical data, with special focus on Cutaneous Melanoma, an immunogenic tumor per excellence. We will describe the different immunotherapeutic strategies employed and consider current models accounting for tumor heterogeneity. And finally, we will propose a rational discussion of the progress made and the future challenges in the therapeutics of Cutaneous Melanoma, taking into consideration that tumor evolution is the resulting from a continuous feedback between tumor cells and their environment, and that different combinatorial therapeutic approaches can be implemented according to the tumor stage. |
| format | Article |
| id | doaj-art-da741e25fde146eab6d7b20580858d0e |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-da741e25fde146eab6d7b20580858d0e2025-02-03T01:09:33ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/192719192719Lessons from Cancer Immunoediting in Cutaneous MelanomaMariana Aris0María Marcela Barrio1José Mordoh2Laboratorio de Cancerología, Fundación Instituto Leloir, IIBBA-CONICET, Avenida Patricias Argentinas 435, 1405 Buenos Aires, ArgentinaCentro de Investigaciones Oncológicas, Fundación Cáncer and Instituto Alexander Fleming, 1426 Buenos Aires, ArgentinaLaboratorio de Cancerología, Fundación Instituto Leloir, IIBBA-CONICET, Avenida Patricias Argentinas 435, 1405 Buenos Aires, ArgentinaWe will revisit the dual role of the immune system in controlling and enabling tumor progression, known as cancer immunoediting. We will go through the different phases of this phenomenon, exposing the most relevant evidences obtained from experimental models and human clinical data, with special focus on Cutaneous Melanoma, an immunogenic tumor per excellence. We will describe the different immunotherapeutic strategies employed and consider current models accounting for tumor heterogeneity. And finally, we will propose a rational discussion of the progress made and the future challenges in the therapeutics of Cutaneous Melanoma, taking into consideration that tumor evolution is the resulting from a continuous feedback between tumor cells and their environment, and that different combinatorial therapeutic approaches can be implemented according to the tumor stage.http://dx.doi.org/10.1155/2012/192719 |
| spellingShingle | Mariana Aris María Marcela Barrio José Mordoh Lessons from Cancer Immunoediting in Cutaneous Melanoma Clinical and Developmental Immunology |
| title | Lessons from Cancer Immunoediting in Cutaneous Melanoma |
| title_full | Lessons from Cancer Immunoediting in Cutaneous Melanoma |
| title_fullStr | Lessons from Cancer Immunoediting in Cutaneous Melanoma |
| title_full_unstemmed | Lessons from Cancer Immunoediting in Cutaneous Melanoma |
| title_short | Lessons from Cancer Immunoediting in Cutaneous Melanoma |
| title_sort | lessons from cancer immunoediting in cutaneous melanoma |
| url | http://dx.doi.org/10.1155/2012/192719 |
| work_keys_str_mv | AT marianaaris lessonsfromcancerimmunoeditingincutaneousmelanoma AT mariamarcelabarrio lessonsfromcancerimmunoeditingincutaneousmelanoma AT josemordoh lessonsfromcancerimmunoeditingincutaneousmelanoma |