Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations
Two titrimetric and two spectrophotometric methods are described for the assay of famotidine (FMT) in tablets using N-bromosuccinimide (NBS). The first titrimetric method is direct in which FMT is titrated directly with NBS in HCl medium using methyl orange as indicator (method A). The remaining thr...
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Wiley
2011-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/581372 |
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| author | O. Zenita K. Basavaiah |
| author_facet | O. Zenita K. Basavaiah |
| author_sort | O. Zenita |
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| description | Two titrimetric and two spectrophotometric methods are described for the assay of famotidine (FMT) in tablets using N-bromosuccinimide (NBS). The first titrimetric method is direct in which FMT is titrated directly with NBS in HCl medium using methyl orange as indicator (method A). The remaining three methods are indirect in which the unreacted NBS is determined after the complete reaction between FMT and NBS by iodometric back titration (method B) or by reacting with a fixed amount of either indigo carmine (method C) or neutral red (method D). The method A and method B are applicable over the range of 2–9 mg and 1–7 mg, respectively. In spectrophotometric methods, Beer's law is obeyed over the concentration ranges of 0.75–6.0 μg mL-1 (method C) and 0.3–3.0 μg mL-1 (method D). The applicability of the developed methods was demonstrated by the determination of FMT in pure drug as well as in tablets. |
| format | Article |
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| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
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| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-da5ab6135ecd4c72987a2be2213dcba42025-02-03T05:52:00ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792011-01-01201110.1155/2011/581372581372Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical FormulationsO. Zenita0K. Basavaiah1Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570 006, IndiaDepartment of Chemistry, University of Mysore, Manasagangothri, Mysore 570 006, IndiaTwo titrimetric and two spectrophotometric methods are described for the assay of famotidine (FMT) in tablets using N-bromosuccinimide (NBS). The first titrimetric method is direct in which FMT is titrated directly with NBS in HCl medium using methyl orange as indicator (method A). The remaining three methods are indirect in which the unreacted NBS is determined after the complete reaction between FMT and NBS by iodometric back titration (method B) or by reacting with a fixed amount of either indigo carmine (method C) or neutral red (method D). The method A and method B are applicable over the range of 2–9 mg and 1–7 mg, respectively. In spectrophotometric methods, Beer's law is obeyed over the concentration ranges of 0.75–6.0 μg mL-1 (method C) and 0.3–3.0 μg mL-1 (method D). The applicability of the developed methods was demonstrated by the determination of FMT in pure drug as well as in tablets.http://dx.doi.org/10.1155/2011/581372 |
| spellingShingle | O. Zenita K. Basavaiah Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations International Journal of Analytical Chemistry |
| title | Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations |
| title_full | Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations |
| title_fullStr | Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations |
| title_full_unstemmed | Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations |
| title_short | Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations |
| title_sort | utility of n bromosuccinimide for the titrimetric and spectrophotometric determination of famotidine in pharmaceutical formulations |
| url | http://dx.doi.org/10.1155/2011/581372 |
| work_keys_str_mv | AT ozenita utilityofnbromosuccinimideforthetitrimetricandspectrophotometricdeterminationoffamotidineinpharmaceuticalformulations AT kbasavaiah utilityofnbromosuccinimideforthetitrimetricandspectrophotometricdeterminationoffamotidineinpharmaceuticalformulations |